Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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MAPK7

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
MAPK7	ERK5,BMK1, ERK5	mitogen-activated protein kinase 7	NM_139033	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

The ensemble annotation is too long (ca 7000 bases) and compared to BLAST against hg19 at the opposite strand. UCSC shows in this 7000 nc long location the MFAP4 gene, directly upstream of MAPK7. Although the BLAST E-values are very good (around 1e-100), nearly zero reads map to the bat cells contigs (no expression was detected) which is strange for a MAP kinase related protein.

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