MAPK7

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAPK7 ERK5,BMK1, ERK5 mitogen-activated protein kinase 7 NM_139033 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.

The ensemble annotation is too long (ca 7000 bases) and compared to BLAST against hg19 at the opposite strand. UCSC shows in this 7000 nc long location the MFAP4 gene, directly upstream of MAPK7. Although the BLAST E-values are very good (around 1e-100), nearly zero reads map to the bat cells contigs (no expression was detected) which is strange for a MAP kinase related protein.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome38 44 41 37 47 41 44 52 31
Read_Max
batR. aegyptiacusTranscriptome 42 45 32 45 28 43 34 43 53
Read_Max
bat_genomeR. aegyptiacusGenome 48 48 29 36 23 24 29 54 62
DESeq
humanH. sapiensGenome 462.73 506.86 370.33 478.95 455.44 402.36 445.74 555.75 435.94
DESeq
batR. aegyptiacusTranscriptome 465.6 418.54 393.11 387.41 379.9 380.82 397.02 444.67 461.1
DESeq
bat_genomeR. aegyptiacusGenome 515.63 448.13 461.93 490.78 455.38 437.31 425.07 513.83 535.98

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 462.73 478.95 445.74 0.05 -0.05 -0.1
7h 506.86 455.44 555.75 -0.15 0.13 0.29
23h 370.33 402.36 435.94 0.12 0.24 0.12

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 462.73 506.86 370.33 0.13 -0.32 -0.45
Ebov 478.95 455.44 402.36 -0.07 -0.25 -0.18
Marv 445.74 555.75 435.94 0.32 -0.03 -0.35

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 465.6 387.41 397.02 -0.27 -0.23 0.04
7h 418.54 379.9 444.67 -0.14 0.09 0.23
23h 393.11 380.82 461.1 -0.05 0.23 0.28

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 465.6 418.54 393.11 -0.15 -0.24 -0.09
Ebov 387.41 379.9 380.82 -0.03 -0.02 0.0
Marv 397.02 444.67 461.1 0.16 0.22 0.05