FADD

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FADD GIG3, MORT1,MORT1, GIG3 Fas (TNFRSF6)-associated via death domain NM_003824 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

For this gene, no interesting differences in the expression patterns were found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome93 128 80 94 106 88 148 180 110
Read_Max
batR. aegyptiacusTranscriptome 138 121 96 103 110 168 110 133 177
Read_Max
bat_genomeR. aegyptiacusGenome 166 149 129 161 100 156 125 197 243
DESeq
humanH. sapiensGenome 622.05 707.77 634.42 806.32 676.56 468.15 767.68 871.49 926.33
DESeq
batR. aegyptiacusTranscriptome 513.49 510.21 550.69 435.94 567.16 693.92 551.64 422.37 586.18
DESeq
bat_genomeR. aegyptiacusGenome 1372.45 1251.29 1370.18 1666.87 1516.83 2114.76 1518.12 1247.3 1535.15

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 622.05 806.32 767.68 0.37 0.3 -0.07
7h 707.77 676.56 871.49 -0.07 0.3 0.37
23h 634.42 468.15 926.33 -0.44 0.55 0.98

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 622.05 707.77 634.42 0.19 0.03 -0.16
Ebov 806.32 676.56 468.15 -0.25 -0.78 -0.53
Marv 767.68 871.49 926.33 0.18 0.27 0.09

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 513.49 435.94 551.64 -0.24 0.1 0.34
7h 510.21 567.16 422.37 0.15 -0.27 -0.43
23h 550.69 693.92 586.18 0.33 0.09 -0.24

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 513.49 510.21 550.69 -0.01 0.1 0.11
Ebov 435.94 567.16 693.92 0.38 0.67 0.29
Marv 551.64 422.37 586.18 -0.39 0.09 0.47