RELA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RELA	NFKB3, p65,p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	NM_021975	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA.

The gene is 2-fold upregulated exclusively in the human cells Ebola 23 h sample.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	64	104	83	90	109	262	109	147	82
Read_Max	R. aegyptiacus	Transcriptome	206	217	170	156	142	195	146	169	243
Read_Max	R. aegyptiacus	Genome	223	159	153	206	134	117	124	219	264
DESeq	H. sapiens	Genome	682.94	1025.97	692.01	995.68	816.39	2315.71	1038.73	1196.03	863.27
DESeq	R. aegyptiacus	Transcriptome	1754.37	1751.93	1939.58	1384.57	1402.72	2081.04	1605.09	1353.5	1677.82
DESeq	R. aegyptiacus	Genome	2088.32	1706.72	2346.48	2175.43	1840.5	2802.72	1991.55	1665.98	2049.72

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	682.94	995.68	1038.73	0.54	0.6	0.06
7h	1025.97	816.39	1196.03	-0.33	0.22	0.55
23h	692.01	2315.71	863.27	1.74	0.32	-1.42

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	682.94	1025.97	692.01	0.59	0.02	-0.57
Ebov	995.68	816.39	2315.71	-0.29	1.22	1.5
Marv	1038.73	1196.03	863.27	0.2	-0.27	-0.47

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1754.37	1384.57	1605.09	-0.34	-0.13	0.21
7h	1751.93	1402.72	1353.5	-0.32	-0.37	-0.05
23h	1939.58	2081.04	1677.82	0.1	-0.21	-0.31

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1754.37	1751.93	1939.58	-0.0	0.14	0.15
Ebov	1384.57	1402.72	2081.04	0.02	0.59	0.57
Marv	1605.09	1353.5	1677.82	-0.25	0.06	0.31

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material