HERC5
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| HERC5 | CEB1,CEBP1 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | NM_016323 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
Low expression in human cells and bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 14 | 11 | 10 | 8 | 16 | 16 | 11 | 8 | 11 |
Read_Max |  | R. aegyptiacus | Transcriptome | 24 | 23 | 20 | 16 | 16 | 20 | 16 | 23 | 23 |
Read_Max |  | R. aegyptiacus | Genome | 30 | 20 | 17 | 19 | 13 | 13 | 18 | 32 | 39 |
DESeq | | H. sapiens | Genome | 135.97 | 83.61 | 110.21 | 76.29 | 100.99 | 162.86 | 83.46 | 78.54 | 126.04 |
DESeq | | R. aegyptiacus | Transcriptome | 198.43 | 168.01 | 248.97 | 147.51 | 167.45 | 247.37 | 183.43 | 178.63 | 222.3 |
DESeq | | R. aegyptiacus | Genome | 391.02 | 353.21 | 405.03 | 261.68 | 266.76 | 386.4 | 293.5 | 305.28 | 357.03 |