HERC5

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HERC5 CEB1,CEBP1 HECT and RLD domain containing E3 ubiquitin protein ligase 5 NM_016323 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.

Low expression in human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome14 11 10 8 16 16 11 8 11
Read_Max
batR. aegyptiacusTranscriptome 24 23 20 16 16 20 16 23 23
Read_Max
bat_genomeR. aegyptiacusGenome 30 20 17 19 13 13 18 32 39
DESeq
humanH. sapiensGenome 135.97 83.61 110.21 76.29 100.99 162.86 83.46 78.54 126.04
DESeq
batR. aegyptiacusTranscriptome 198.43 168.01 248.97 147.51 167.45 247.37 183.43 178.63 222.3
DESeq
bat_genomeR. aegyptiacusGenome 391.02 353.21 405.03 261.68 266.76 386.4 293.5 305.28 357.03

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 135.97 76.29 83.46 -0.83 -0.7 0.13
7h 83.61 100.99 78.54 0.27 -0.09 -0.36
23h 110.21 162.86 126.04 0.56 0.19 -0.37

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 135.97 83.61 110.21 -0.7 -0.3 0.4
Ebov 76.29 100.99 162.86 0.4 1.09 0.69
Marv 83.46 78.54 126.04 -0.09 0.59 0.68

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 198.43 147.51 183.43 -0.43 -0.11 0.31
7h 168.01 167.45 178.63 -0.0 0.09 0.09
23h 248.97 247.37 222.3 -0.01 -0.16 -0.15

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 198.43 168.01 248.97 -0.24 0.33 0.57
Ebov 147.51 167.45 247.37 0.18 0.75 0.56
Marv 183.43 178.63 222.3 -0.04 0.28 0.32