IFNG

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IFNG interferon, gamma pdf NONE

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Description

This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages.

The expression of this gene is repressed bey Ebola and Marburg in human cells, but is highly expressed in the bat cells. This may be among the reasons that fruit bats survive an infection.

Schmidt et al.~\cite{schmidt11kaposis conclude that the gene vIRF-3 of Kaposi's sarcoma-associated herpesvirus (KSHV) contributes to the viral immunoevasion by downregulation of gamma interferon (IFNG) and CIITA and thus MHC II expression.}

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome0 0 0 0 0 0 0 0 0
Read_Max
batR. aegyptiacusTranscriptome 63 34 65 65 54 66 37 72 84
Read_Max
bat_genomeR. aegyptiacusGenome 67 80 75 46 48 66 33 105 149
DESeq
humanH. sapiensGenome 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
DESeq
batR. aegyptiacusTranscriptome 151.39 106.29 261.19 184.13 167.45 222.99 117.8 193.51 274.78
DESeq
bat_genomeR. aegyptiacusGenome 244.93 381.5 518.84 174.78 331.49 443.84 226.03 383.79 612.18

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 1.0 1.0 0.0 0.0 0.0
23h 1.0 1.0 1.0 0.0 0.0 0.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 1.0 1.0 1.0 0.0 0.0 0.0

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 151.39 184.13 117.8 0.28 -0.36 -0.64
7h 106.29 167.45 193.51 0.66 0.86 0.21
23h 261.19 222.99 274.78 -0.23 0.07 0.3

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 151.39 106.29 261.19 -0.51 0.79 1.3
Ebov 184.13 167.45 222.99 -0.14 0.28 0.41
Marv 117.8 193.51 274.78 0.72 1.22 0.51