Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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IFNG

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
IFNG		interferon, gamma		pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages.

The expression of this gene is repressed bey Ebola and Marburg in human cells, but is highly expressed in the bat cells. This may be among the reasons that fruit bats survive an infection.

Schmidt et al.~\cite{schmidt11kaposis conclude that the gene vIRF-3 of Kaposi's sarcoma-associated herpesvirus (KSHV) contributes to the viral immunoevasion by downregulation of gamma interferon (IFNG) and CIITA and thus MHC II expression.}

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source		Species	Mapping on	Mock3h	Mock7h	Mock23h	EBOV3h	EBOV7h	EBOV23h	MARV3h	MARV7h	MARV23h
Read_Max		H. sapiens	Genome	0	0	0	0	0	0	0	0	0
Read_Max		R. aegyptiacus	Transcriptome	63	34	65	65	54	66	37	72	84
Read_Max		R. aegyptiacus	Genome	67	80	75	46	48	66	33	105	149
DESeq		H. sapiens	Genome	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0	1.0
DESeq		R. aegyptiacus	Transcriptome	151.39	106.29	261.19	184.13	167.45	222.99	117.8	193.51	274.78
DESeq		R. aegyptiacus	Genome	244.93	381.5	518.84	174.78	331.49	443.84	226.03	383.79	612.18

Human Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	1.0	1.0	1.0	0.0	0.0	0.0
7h	1.0	1.0	1.0	0.0	0.0	0.0
23h	1.0	1.0	1.0	0.0	0.0	0.0

Human Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	1.0	1.0	1.0	0.0	0.0	0.0
Ebov	1.0	1.0	1.0	0.0	0.0	0.0
Marv	1.0	1.0	1.0	0.0	0.0	0.0

Bat Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	151.39	184.13	117.8	0.28	-0.36	-0.64
7h	106.29	167.45	193.51	0.66	0.86	0.21
23h	261.19	222.99	274.78	-0.23	0.07	0.3

Bat Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	151.39	106.29	261.19	-0.51	0.79	1.3
Ebov	184.13	167.45	222.99	-0.14	0.28	0.41
Marv	117.8	193.51	274.78	0.72	1.22	0.51