RCHY1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RCHY1	ZCHY, ARNIP, CHIMP, PIRH2, RNF199, ZNF363, PRO1996,CHIMP, DKFZp586C1620, ZCHY	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	NM_015436	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

The exon annotation of the gene displays not the expression from the RNA-Seq data. The first exons are not used.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	143	112	88	139	171	268	185	177	86
Read_Max	R. aegyptiacus	Transcriptome	79	90	104	89	78	104	65	103	115
Read_Max	R. aegyptiacus	Genome	87	93	83	88	68	67	60	131	132
DESeq	H. sapiens	Genome	1131.47	833.22	808.17	1016.21	996.05	1212.96	1089.61	924.25	839.34
DESeq	R. aegyptiacus	Transcriptome	295.89	324.14	440.75	392.91	376.62	414.18	336.95	442.2	369.25
DESeq	R. aegyptiacus	Genome	669.46	796.77	861.38	612.24	789.11	789.77	741.07	915.06	791.98

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1131.47	1016.21	1089.61	-0.15	-0.05	0.1
7h	833.22	996.05	924.25	0.26	0.15	-0.11
23h	808.17	1212.96	839.34	0.59	0.05	-0.53

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1131.47	833.22	808.17	-0.44	-0.49	-0.04
Ebov	1016.21	996.05	1212.96	-0.03	0.26	0.28
Marv	1089.61	924.25	839.34	-0.24	-0.38	-0.14

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	295.89	392.91	336.95	0.41	0.19	-0.22
7h	324.14	376.62	442.2	0.22	0.45	0.23
23h	440.75	414.18	369.25	-0.09	-0.26	-0.17

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	295.89	324.14	440.75	0.13	0.57	0.44
Ebov	392.91	376.62	414.18	-0.06	0.08	0.14
Marv	336.95	442.2	369.25	0.39	0.13	-0.26

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material