ILF2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ILF2 NF45 interleukin enhancer binding factor 2 NM_004515 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is the 45 kDa component of nuclear factor of activated T-cells (NFAT), a heterodimer of 45 kDa and 90 kDa proteins. NFAT is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The complex has been shown to repair DNA breaks by nonhomologous end joining and can also negatively regulate the microRNA processing pathway. Alternative splicing results in multiple transcript variants.

The gene shows relatively high expression with slight variations, with Marburg after 23 h showing less expression.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1373 1482 1129 1398 1720 1747 1935 2122 1004
Read_Max
batR. aegyptiacusTranscriptome 294 239 232 237 218 217 215 308 299
Read_Max
bat_genomeR. aegyptiacusGenome 797 674 555 588 512 337 432 976 870
DESeq
humanH. sapiensGenome 9310.65 9933.54 8751.76 10218.1 9806.81 11331.09 10588.86 10164.74 8163.71
DESeq
batR. aegyptiacusTranscriptome 1420.84 1326.23 1360.57 1144.67 1234.07 1117.37 1275.82 1186.61 1162.61
DESeq
bat_genomeR. aegyptiacusGenome 3666.16 3405.23 3617.35 3977.58 3635.25 3531.13 3535.53 3499.27 3519.8

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 9310.65 10218.1 10588.86 0.13 0.19 0.05
7h 9933.54 9806.81 10164.74 -0.02 0.03 0.05
23h 8751.76 11331.09 8163.71 0.37 -0.1 -0.47

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 9310.65 9933.54 8751.76 0.09 -0.09 -0.18
Ebov 10218.1 9806.81 11331.09 -0.06 0.15 0.21
Marv 10588.86 10164.74 8163.71 -0.06 -0.38 -0.32

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1420.84 1144.67 1275.82 -0.31 -0.16 0.16
7h 1326.23 1234.07 1186.61 -0.1 -0.16 -0.06
23h 1360.57 1117.37 1162.61 -0.28 -0.23 0.06

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1420.84 1326.23 1360.57 -0.1 -0.06 0.04
Ebov 1144.67 1234.07 1117.37 0.11 -0.03 -0.14
Marv 1275.82 1186.61 1162.61 -0.1 -0.13 -0.03