PPP1CB

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PPP1CB	PP1B, PP-1B, PP1beta	protein phosphatase 1, catalytic subunit, beta isozyme		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.

Only the EBOV-23h infected human cells cells show a few 3'UTR-extended transcripts.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	580	470	488	477	708	596	523	574	505
Read_Max	R. aegyptiacus	Transcriptome	1550	1387	1090	1346	1222	1377	1251	1710	1513
Read_Max	R. aegyptiacus	Genome	1905	1493	920	1374	1044	784	1089	2072	1640
DESeq	H. sapiens	Genome	8605.38	5937.68	8026.99	6670.57	7837.03	6803.0	6259.86	5039.31	8175.67
DESeq	R. aegyptiacus	Transcriptome	6850.67	6501.87	6919.78	7723.75	7812.28	7603.85	8057.04	8374.62	6944.44
DESeq	R. aegyptiacus	Genome	12406.15	14083.64	11913.16	12351.44	14498.58	14315.13	15306.01	15065.18	12531.22

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8605.38	6670.57	6259.86	-0.37	-0.46	-0.09
7h	5937.68	7837.03	5039.31	0.4	-0.24	-0.64
23h	8026.99	6803.0	8175.67	-0.24	0.03	0.27

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8605.38	5937.68	8026.99	-0.54	-0.1	0.43
Ebov	6670.57	7837.03	6803.0	0.23	0.03	-0.2
Marv	6259.86	5039.31	8175.67	-0.31	0.39	0.7

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6850.67	7723.75	8057.04	0.17	0.23	0.06
7h	6501.87	7812.28	8374.62	0.26	0.37	0.1
23h	6919.78	7603.85	6944.44	0.14	0.01	-0.13

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6850.67	6501.87	6919.78	-0.08	0.01	0.09
Ebov	7723.75	7812.28	7603.85	0.02	-0.02	-0.04
Marv	8057.04	8374.62	6944.44	0.06	-0.21	-0.27

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material