PPP1CB

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PPP1CB PP1B, PP-1B, PP1beta protein phosphatase 1, catalytic subunit, beta isozyme pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.

Only the EBOV-23h infected human cells cells show a few 3'UTR-extended transcripts.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome580 470 488 477 708 596 523 574 505
Read_Max
batR. aegyptiacusTranscriptome 1550 1387 1090 1346 1222 1377 1251 1710 1513
Read_Max
bat_genomeR. aegyptiacusGenome 1905 1493 920 1374 1044 784 1089 2072 1640
DESeq
humanH. sapiensGenome 8605.38 5937.68 8026.99 6670.57 7837.03 6803.0 6259.86 5039.31 8175.67
DESeq
batR. aegyptiacusTranscriptome 6850.67 6501.87 6919.78 7723.75 7812.28 7603.85 8057.04 8374.62 6944.44
DESeq
bat_genomeR. aegyptiacusGenome 12406.15 14083.64 11913.16 12351.44 14498.58 14315.13 15306.01 15065.18 12531.22

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8605.38 6670.57 6259.86 -0.37 -0.46 -0.09
7h 5937.68 7837.03 5039.31 0.4 -0.24 -0.64
23h 8026.99 6803.0 8175.67 -0.24 0.03 0.27

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8605.38 5937.68 8026.99 -0.54 -0.1 0.43
Ebov 6670.57 7837.03 6803.0 0.23 0.03 -0.2
Marv 6259.86 5039.31 8175.67 -0.31 0.39 0.7

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6850.67 7723.75 8057.04 0.17 0.23 0.06
7h 6501.87 7812.28 8374.62 0.26 0.37 0.1
23h 6919.78 7603.85 6944.44 0.14 0.01 -0.13

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6850.67 6501.87 6919.78 -0.08 0.01 0.09
Ebov 7723.75 7812.28 7603.85 0.02 -0.02 -0.04
Marv 8057.04 8374.62 6944.44 0.06 -0.21 -0.27