KEAP1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| KEAP1 | INrf2, KLHL19,KIAA0132, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454, INrf2, KLHL19 | kelch-like ECH-associated protein 1 | NM_012289 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
It is constantly expressed in human cells and bat cells in all examined conditions.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 91 | 143 | 106 | 126 | 186 | 184 | 154 | 260 | 158 |
Read_Max |  | R. aegyptiacus | Transcriptome | 70 | 59 | 38 | 60 | 61 | 56 | 42 | 77 | 91 |
Read_Max |  | R. aegyptiacus | Genome | 374 | 319 | 166 | 319 | 215 | 148 | 203 | 439 | 392 |
DESeq | | H. sapiens | Genome | 1608.42 | 1762.32 | 1345.28 | 1647.01 | 1690.31 | 2276.23 | 1782.6 | 2423.03 | 2070.22 |
DESeq | | R. aegyptiacus | Transcriptome | 295.05 | 303.26 | 224.54 | 292.18 | 316.39 | 276.88 | 296.9 | 305.04 | 334.26 |
DESeq | | R. aegyptiacus | Genome | 3441.0 | 3427.13 | 2827.38 | 4013.13 | 3585.02 | 3341.85 | 3678.34 | 3514.34 | 3561.76 |