APC

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
APC DP2, DP3, DP2.5, PPP1R46 adenomatous polyposis coli NM_000038 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

The APC gene is not altered in expression through infection of both viruses.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome105 101 70 82 103 96 92 101 60
Read_Max
batR. aegyptiacusTranscriptome 219 157 134 221 179 215 184 210 222
Read_Max
bat_genomeR. aegyptiacusGenome 254 240 119 158 151 133 165 261 260
DESeq
humanH. sapiensGenome 4069.28 3401.26 3164.14 3530.27 3453.6 3515.83 3277.36 2706.8 2891.17
DESeq
batR. aegyptiacusTranscriptome 6024.81 4655.63 4834.62 5848.46 5895.87 7132.92 6442.94 5081.36 4942.23
DESeq
bat_genomeR. aegyptiacusGenome 7224.89 6794.94 5419.33 5850.84 6992.58 8576.54 7718.79 5922.51 5783.57

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4069.28 3530.27 3277.36 -0.2 -0.31 -0.11
7h 3401.26 3453.6 2706.8 0.02 -0.33 -0.35
23h 3164.14 3515.83 2891.17 0.15 -0.13 -0.28

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4069.28 3401.26 3164.14 -0.26 -0.36 -0.1
Ebov 3530.27 3453.6 3515.83 -0.03 -0.01 0.03
Marv 3277.36 2706.8 2891.17 -0.28 -0.18 0.1

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6024.81 5848.46 6442.94 -0.04 0.1 0.14
7h 4655.63 5895.87 5081.36 0.34 0.13 -0.21
23h 4834.62 7132.92 4942.23 0.56 0.03 -0.53

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6024.81 4655.63 4834.62 -0.37 -0.32 0.05
Ebov 5848.46 5895.87 7132.92 0.01 0.29 0.27
Marv 6442.94 5081.36 4942.23 -0.34 -0.38 -0.04