DDIT3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DDIT3 CHOP, CHOP10,GADD153,CHOP10, GADD153, CHOP DNA-damage-inducible transcript 3 NM_004083 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Equally expressed in human cells and bat cells under all conditions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome39 43 92 32 86 380 35 50 87
Read_Max
batR. aegyptiacusTranscriptome 20 13 24 16 16 79 7 25 28
Read_Max
bat_genomeR. aegyptiacusGenome 43 46 39 29 37 91 20 74 56
DESeq
humanH. sapiensGenome 195.84 229.45 290.9 228.0 325.37 2060.42 195.74 257.59 289.15
DESeq
batR. aegyptiacusTranscriptome 69.05 43.66 106.05 48.61 60.13 401.35 28.81 92.71 95.47
DESeq
bat_genomeR. aegyptiacusGenome 246.64 291.15 432.92 174.78 265.64 903.34 170.93 341.76 356.18

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 195.84 228.0 195.74 0.22 -0.0 -0.22
7h 229.45 325.37 257.59 0.5 0.17 -0.34
23h 290.9 2060.42 289.15 2.82 -0.01 -2.83

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 195.84 229.45 290.9 0.23 0.57 0.34
Ebov 228.0 325.37 2060.42 0.51 3.18 2.66
Marv 195.74 257.59 289.15 0.4 0.56 0.17

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 69.05 48.61 28.81 -0.51 -1.26 -0.75
7h 43.66 60.13 92.71 0.46 1.09 0.62
23h 106.05 401.35 95.47 1.92 -0.15 -2.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 69.05 43.66 106.05 -0.66 0.62 1.28
Ebov 48.61 60.13 401.35 0.31 3.05 2.74
Marv 28.81 92.71 95.47 1.69 1.73 0.04