STAT1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
STAT1	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91,STAT91	signal transducer and activator of transcription 1, 91kDa	NM_007315	pdf

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Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

This gene is expressed in human cells and bat cells in all probes. While the gene is slightly differentially expressed (upregulated in 7h, downregulated in 23h), this pattern is the same for the infected and the uninfected probes. The retrogene retro-RAB1A is strongly expressed in all probes in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	301	343	246	319	389	258	399	433	204
Read_Max	R. aegyptiacus	Transcriptome	200	196	190	191	182	231	153	224	250
Read_Max	R. aegyptiacus	Genome	213	194	160	181	142	106	132	267	270
DESeq	H. sapiens	Genome	4511.73	4404.81	3639.7	4577.42	4308.83	2842.08	4408.95	4333.48	3510.96
DESeq	R. aegyptiacus	Transcriptome	1812.34	1672.06	2120.37	1969.69	1994.06	1937.32	1828.68	2037.6	2120.42
DESeq	R. aegyptiacus	Genome	2126.13	2250.68	2279.53	2027.3	2301.47	2194.39	2141.11	2277.34	2423.88

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	4511.73	4577.42	4408.95	0.02	-0.03	-0.05
7h	4404.81	4308.83	4333.48	-0.03	-0.02	0.01
23h	3639.7	2842.08	3510.96	-0.36	-0.05	0.3

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	4511.73	4404.81	3639.7	-0.03	-0.31	-0.28
Ebov	4577.42	4308.83	2842.08	-0.09	-0.69	-0.6
Marv	4408.95	4333.48	3510.96	-0.02	-0.33	-0.3

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1812.34	1969.69	1828.68	0.12	0.01	-0.11
7h	1672.06	1994.06	2037.6	0.25	0.29	0.03
23h	2120.37	1937.32	2120.42	-0.13	0.0	0.13

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1812.34	1672.06	2120.37	-0.12	0.23	0.34
Ebov	1969.69	1994.06	1937.32	0.02	-0.02	-0.04
Marv	1828.68	2037.6	2120.42	0.16	0.21	0.06

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material