STAT1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
STAT1 STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91,STAT91 signal transducer and activator of transcription 1, 91kDa NM_007315 pdf

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Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

This gene is expressed in human cells and bat cells in all probes. While the gene is slightly differentially expressed (upregulated in 7h, downregulated in 23h), this pattern is the same for the infected and the uninfected probes. The retrogene retro-RAB1A is strongly expressed in all probes in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome301 343 246 319 389 258 399 433 204
Read_Max
batR. aegyptiacusTranscriptome 200 196 190 191 182 231 153 224 250
Read_Max
bat_genomeR. aegyptiacusGenome 213 194 160 181 142 106 132 267 270
DESeq
humanH. sapiensGenome 4511.73 4404.81 3639.7 4577.42 4308.83 2842.08 4408.95 4333.48 3510.96
DESeq
batR. aegyptiacusTranscriptome 1812.34 1672.06 2120.37 1969.69 1994.06 1937.32 1828.68 2037.6 2120.42
DESeq
bat_genomeR. aegyptiacusGenome 2126.13 2250.68 2279.53 2027.3 2301.47 2194.39 2141.11 2277.34 2423.88

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4511.73 4577.42 4408.95 0.02 -0.03 -0.05
7h 4404.81 4308.83 4333.48 -0.03 -0.02 0.01
23h 3639.7 2842.08 3510.96 -0.36 -0.05 0.3

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4511.73 4404.81 3639.7 -0.03 -0.31 -0.28
Ebov 4577.42 4308.83 2842.08 -0.09 -0.69 -0.6
Marv 4408.95 4333.48 3510.96 -0.02 -0.33 -0.3

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1812.34 1969.69 1828.68 0.12 0.01 -0.11
7h 1672.06 1994.06 2037.6 0.25 0.29 0.03
23h 2120.37 1937.32 2120.42 -0.13 0.0 0.13

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1812.34 1672.06 2120.37 -0.12 0.23 0.34
Ebov 1969.69 1994.06 1937.32 0.02 -0.02 -0.04
Marv 1828.68 2037.6 2120.42 0.16 0.21 0.06