VPS16
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| VPS16 | vacuolar protein sorting 16 homolog (S. cerevisiae) | NM_022575 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.
The gene shows slight upregulation in human cells in Ebola and Marburg infected cells, and almost no change in the bat cells homologues.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 46 | 75 | 63 | 61 | 98 | 145 | 78 | 89 | 65 |
Read_Max |  | R. aegyptiacus | Transcriptome | 40 | 39 | 40 | 38 | 31 | 41 | 41 | 51 | 56 |
Read_Max |  | R. aegyptiacus | Genome | 83 | 80 | 65 | 65 | 54 | 44 | 46 | 110 | 96 |
DESeq | | H. sapiens | Genome | 657.57 | 947.44 | 833.98 | 848.53 | 859.48 | 1543.26 | 915.92 | 1028.17 | 780.63 |
DESeq | | R. aegyptiacus | Transcriptome | 527.77 | 463.92 | 544.58 | 467.08 | 481.74 | 524.54 | 493.8 | 528.95 | 558.19 |
DESeq | | R. aegyptiacus | Genome | 1018.38 | 1023.12 | 1059.99 | 981.56 | 978.85 | 989.5 | 870.39 | 1014.97 | 1029.14 |