EDEM3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
EDEM3 C1orf22 ER degradation enhancer, mannosidase alpha-like 3 NM_025191 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER~\citehirao06edem3.

Generally well expressed in human cells and bat cells. In human cells, cells infected with Ebola show an upregulation of EDEM3 after 3 h and a downregulation after 23 h of infection. This pattern is not observed in the wild type or in Marburg infected cells, also not in bat cells. In fact in bat cells, Ebola-infected cells are slightly down-regulated after infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome256 270 319 232 435 180 266 315 319
Read_Max
batR. aegyptiacusTranscriptome 315 249 169 250 232 190 264 268 213
Read_Max
bat_genomeR. aegyptiacusGenome 354 260 144 239 191 129 235 333 322
DESeq
humanH. sapiensGenome 6913.73 7061.58 7468.03 6053.46 7847.6 3750.06 5645.81 6003.32 8121.31
DESeq
batR. aegyptiacusTranscriptome 4663.78 3847.79 3486.04 4106.86 4505.11 2997.23 4890.02 4164.26 3275.91
DESeq
bat_genomeR. aegyptiacusGenome 7654.59 6542.13 5337.88 6635.89 7558.46 5322.16 8857.94 6923.21 5587.51

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6913.73 6053.46 5645.81 -0.19 -0.29 -0.1
7h 7061.58 7847.6 6003.32 0.15 -0.23 -0.39
23h 7468.03 3750.06 8121.31 -0.99 0.12 1.11

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6913.73 7061.58 7468.03 0.03 0.11 0.08
Ebov 6053.46 7847.6 3750.06 0.37 -0.69 -1.07
Marv 5645.81 6003.32 8121.31 0.09 0.52 0.44

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4663.78 4106.86 4890.02 -0.18 0.07 0.25
7h 3847.79 4505.11 4164.26 0.23 0.11 -0.11
23h 3486.04 2997.23 3275.91 -0.22 -0.09 0.13

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4663.78 3847.79 3486.04 -0.28 -0.42 -0.14
Ebov 4106.86 4505.11 2997.23 0.13 -0.45 -0.59
Marv 4890.02 4164.26 3275.91 -0.23 -0.58 -0.35