CDC42

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CDC42 G25K, CDC42Hs cell division cycle 42 NM_001791 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a small GTPase of the Rho-subfamily,which regulates signaling pathways that control diverse cellular functionsincluding cell morphology, migration, endocytosis and cell cycleprogression. This protein is highly similar to Saccharomyces cerevisiae Cdc42, and is able to complement the yeast cdc42-1 mutant. The product ofoncogene Dbl was reported to specifically catalyze the dissociation of GDPfrom this protein. This protein could regulate actin polymerization throughits direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP),which subsequently activates Arp2/3 complex. Alternative splicing of thisgene results in multiple transcript variants. Pseudogenes of this gene havebeen identified on chromosomes 3, 4, 5, 7, 8 and 20.

This gene is slightly downregulated in Marburg infected cells in human cells but slightly upregulated in Marburg infected cells in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1765 1458 1330 1416 2026 1755 1947 1674 1152
Read_Max
batR. aegyptiacusTranscriptome 2336 2470 1684 1776 1474 1756 1608 1997 2286
Read_Max
bat_genomeR. aegyptiacusGenome 2346 1595 1173 2106 1038 876 1176 2030 2094
DESeq
humanH. sapiensGenome 9383.72 6425.18 6030.42 7745.1 7026.52 6514.81 7472.15 5518.12 6383.73
DESeq
batR. aegyptiacusTranscriptome 6376.83 6726.07 5781.31 6056.31 5681.23 5630.32 5966.83 5616.74 6003.25
DESeq
bat_genomeR. aegyptiacusGenome 10735.5 9557.64 8759.97 11400.5 9367.71 9670.48 10241.11 9267.95 9835.93

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 9383.72 7745.1 7472.15 -0.28 -0.33 -0.05
7h 6425.18 7026.52 5518.12 0.13 -0.22 -0.35
23h 6030.42 6514.81 6383.73 0.11 0.08 -0.03

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 9383.72 6425.18 6030.42 -0.55 -0.64 -0.09
Ebov 7745.1 7026.52 6514.81 -0.14 -0.25 -0.11
Marv 7472.15 5518.12 6383.73 -0.44 -0.23 0.21

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6376.83 6056.31 5966.83 -0.07 -0.1 -0.02
7h 6726.07 5681.23 5616.74 -0.24 -0.26 -0.02
23h 5781.31 5630.32 6003.25 -0.04 0.05 0.09

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6376.83 6726.07 5781.31 0.08 -0.14 -0.22
Ebov 6056.31 5681.23 5630.32 -0.09 -0.11 -0.01
Marv 5966.83 5616.74 6003.25 -0.09 0.01 0.1