CDC42

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CDC42	G25K, CDC42Hs	cell division cycle 42	NM_001791	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a small GTPase of the Rho-subfamily,which regulates signaling pathways that control diverse cellular functionsincluding cell morphology, migration, endocytosis and cell cycleprogression. This protein is highly similar to Saccharomyces cerevisiae Cdc42, and is able to complement the yeast cdc42-1 mutant. The product ofoncogene Dbl was reported to specifically catalyze the dissociation of GDPfrom this protein. This protein could regulate actin polymerization throughits direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP),which subsequently activates Arp2/3 complex. Alternative splicing of thisgene results in multiple transcript variants. Pseudogenes of this gene havebeen identified on chromosomes 3, 4, 5, 7, 8 and 20.

This gene is slightly downregulated in Marburg infected cells in human cells but slightly upregulated in Marburg infected cells in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	1765	1458	1330	1416	2026	1755	1947	1674	1152
Read_Max	R. aegyptiacus	Transcriptome	2336	2470	1684	1776	1474	1756	1608	1997	2286
Read_Max	R. aegyptiacus	Genome	2346	1595	1173	2106	1038	876	1176	2030	2094
DESeq	H. sapiens	Genome	9383.72	6425.18	6030.42	7745.1	7026.52	6514.81	7472.15	5518.12	6383.73
DESeq	R. aegyptiacus	Transcriptome	6376.83	6726.07	5781.31	6056.31	5681.23	5630.32	5966.83	5616.74	6003.25
DESeq	R. aegyptiacus	Genome	10735.5	9557.64	8759.97	11400.5	9367.71	9670.48	10241.11	9267.95	9835.93

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	9383.72	7745.1	7472.15	-0.28	-0.33	-0.05
7h	6425.18	7026.52	5518.12	0.13	-0.22	-0.35
23h	6030.42	6514.81	6383.73	0.11	0.08	-0.03

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	9383.72	6425.18	6030.42	-0.55	-0.64	-0.09
Ebov	7745.1	7026.52	6514.81	-0.14	-0.25	-0.11
Marv	7472.15	5518.12	6383.73	-0.44	-0.23	0.21

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	6376.83	6056.31	5966.83	-0.07	-0.1	-0.02
7h	6726.07	5681.23	5616.74	-0.24	-0.26	-0.02
23h	5781.31	5630.32	6003.25	-0.04	0.05	0.09

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	6376.83	6726.07	5781.31	0.08	-0.14	-0.22
Ebov	6056.31	5681.23	5630.32	-0.09	-0.11	-0.01
Marv	5966.83	5616.74	6003.25	-0.09	0.01	0.1

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material