REL

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
REL proto-oncogene c-Rel,I-Rel, c-Rel v-rel avian reticuloendotheliosis viral oncogene homolog NM_002908 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

In human cells the expression increases between 7 h and 23 h after infection with Ebola, but not with Marburg virus or in mock. The bat cells homolog could not be detected in the transcriptome.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome63 62 44 79 64 159 57 43 45
Read_Max
batR. aegyptiacusTranscriptome 85 63 43 67 47 137 63 50 81
Read_Max
bat_genomeR. aegyptiacusGenome 84 58 37 50 35 82 53 59 77
DESeq
humanH. sapiensGenome 634.23 573.15 637.4 656.89 647.3 1828.82 548.38 431.05 541.41
DESeq
batR. aegyptiacusTranscriptome 601.7 485.71 492.06 473.48 489.41 1322.68 646.2 409.97 559.94
DESeq
bat_genomeR. aegyptiacusGenome 1252.13 992.09 801.13 930.21 946.48 2653.9 1226.86 846.87 1055.68

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 634.23 656.89 548.38 0.05 -0.21 -0.26
7h 573.15 647.3 431.05 0.18 -0.41 -0.59
23h 637.4 1828.82 541.41 1.52 -0.24 -1.76

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 634.23 573.15 637.4 -0.15 0.01 0.15
Ebov 656.89 647.3 1828.82 -0.02 1.48 1.5
Marv 548.38 431.05 541.41 -0.35 -0.02 0.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 601.7 473.48 646.2 -0.35 0.1 0.45
7h 485.71 489.41 409.97 0.01 -0.24 -0.26
23h 492.06 1322.68 559.94 1.43 0.19 -1.24

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 601.7 485.71 492.06 -0.31 -0.29 0.02
Ebov 473.48 489.41 1322.68 0.05 1.48 1.43
Marv 646.2 409.97 559.94 -0.66 -0.21 0.45