REL

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
REL	proto-oncogene c-Rel,I-Rel, c-Rel	v-rel avian reticuloendotheliosis viral oncogene homolog	NM_002908	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.

In human cells the expression increases between 7 h and 23 h after infection with Ebola, but not with Marburg virus or in mock. The bat cells homolog could not be detected in the transcriptome.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	63	62	44	79	64	159	57	43	45
Read_Max	R. aegyptiacus	Transcriptome	85	63	43	67	47	137	63	50	81
Read_Max	R. aegyptiacus	Genome	84	58	37	50	35	82	53	59	77
DESeq	H. sapiens	Genome	634.23	573.15	637.4	656.89	647.3	1828.82	548.38	431.05	541.41
DESeq	R. aegyptiacus	Transcriptome	601.7	485.71	492.06	473.48	489.41	1322.68	646.2	409.97	559.94
DESeq	R. aegyptiacus	Genome	1252.13	992.09	801.13	930.21	946.48	2653.9	1226.86	846.87	1055.68

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	634.23	656.89	548.38	0.05	-0.21	-0.26
7h	573.15	647.3	431.05	0.18	-0.41	-0.59
23h	637.4	1828.82	541.41	1.52	-0.24	-1.76

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	634.23	573.15	637.4	-0.15	0.01	0.15
Ebov	656.89	647.3	1828.82	-0.02	1.48	1.5
Marv	548.38	431.05	541.41	-0.35	-0.02	0.33

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	601.7	473.48	646.2	-0.35	0.1	0.45
7h	485.71	489.41	409.97	0.01	-0.24	-0.26
23h	492.06	1322.68	559.94	1.43	0.19	-1.24

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	601.7	485.71	492.06	-0.31	-0.29	0.02
Ebov	473.48	489.41	1322.68	0.05	1.48	1.43
Marv	646.2	409.97	559.94	-0.66	-0.21	0.45

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

REL