MAPK8

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAPK8	JNK-46, JNK, SAPK1c, JNK1,JNK, SAPK1	mitogen-activated protein kinase 8		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.

Expression in both human cells without significant changes. In bat cells Mock we observed a downregulation at 7 h and 23 h.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	122	108	102	120	120	99	127	133	66
Read_Max	R. aegyptiacus	Transcriptome	268	253	181	222	188	327	205	267	243
Read_Max	R. aegyptiacus	Genome	305	241	160	256	155	211	205	364	307
DESeq	H. sapiens	Genome	1154.81	1107.56	1083.18	1303.66	1048.89	918.2	1199.26	980.2	799.11
DESeq	R. aegyptiacus	Transcriptome	1994.65	1904.43	1466.84	1912.92	1800.23	2369.75	2061.18	1894.67	1500.25
DESeq	R. aegyptiacus	Genome	4461.95	4232.12	3210.09	4300.49	4186.62	5216.42	4737.65	4370.72	3521.52

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1154.81	1303.66	1199.26	0.17	0.05	-0.12
7h	1107.56	1048.89	980.2	-0.08	-0.18	-0.1
23h	1083.18	918.2	799.11	-0.24	-0.44	-0.2

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1154.81	1107.56	1083.18	-0.06	-0.09	-0.03
Ebov	1303.66	1048.89	918.2	-0.31	-0.51	-0.19
Marv	1199.26	980.2	799.11	-0.29	-0.59	-0.29

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1994.65	1912.92	2061.18	-0.06	0.05	0.11
7h	1904.43	1800.23	1894.67	-0.08	-0.01	0.07
23h	1466.84	2369.75	1500.25	0.69	0.03	-0.66

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1994.65	1904.43	1466.84	-0.07	-0.44	-0.38
Ebov	1912.92	1800.23	2369.75	-0.09	0.31	0.4
Marv	2061.18	1894.67	1500.25	-0.12	-0.46	-0.34

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material