CREB3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CREB3	LUMAN, LZIP,LZIP, Luman, sLZIP	cAMP responsive element binding protein 3	NM_006368	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

The gene is equally expressed in human cells and bat cells under all investigated conditions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	57	91	90	102	136	182	103	129	100
Read_Max	R. aegyptiacus	Transcriptome	144	145	142	123	102	159	76	148	200
Read_Max	R. aegyptiacus	Genome	185	154	185	188	120	124	100	261	312
DESeq	H. sapiens	Genome	499.26	803.64	652.29	758.41	691.2	1366.93	763.29	752.39	762.14
DESeq	R. aegyptiacus	Transcriptome	715.96	896.89	934.25	697.82	804.8	935.16	602.81	763.59	961.43
DESeq	R. aegyptiacus	Genome	1209.16	1173.71	1407.0	1464.44	1284.67	1467.28	1143.65	1216.38	1518.88

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	499.26	758.41	763.29	0.6	0.61	0.01
7h	803.64	691.2	752.39	-0.22	-0.1	0.12
23h	652.29	1366.93	762.14	1.07	0.22	-0.84

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	499.26	803.64	652.29	0.69	0.39	-0.3
Ebov	758.41	691.2	1366.93	-0.13	0.85	0.98
Marv	763.29	752.39	762.14	-0.02	-0.0	0.02

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	715.96	697.82	602.81	-0.04	-0.25	-0.21
7h	896.89	804.8	763.59	-0.16	-0.23	-0.08
23h	934.25	935.16	961.43	0.0	0.04	0.04

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	715.96	896.89	934.25	0.33	0.38	0.06
Ebov	697.82	804.8	935.16	0.21	0.42	0.22
Marv	602.81	763.59	961.43	0.34	0.67	0.33

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material