TRIM21

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TRIM21	SSA, RO52, SSA1, RNF81, Ro/SSA,RNF81, RO52, Ro/SSA	tripartite motif containing 21	NM_003141	pdf

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Description

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

Very low expression in human, but this is increased in bat cells. In addition, in bat cells the gene is upregulated in Marburg-infected cells (see Fig.~\reffig:igv_bat).

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	4	7	8	3	7	5	11	8	10
Read_Max	R. aegyptiacus	Transcriptome	60	45	63	56	48	62	33	63	89
Read_Max	R. aegyptiacus	Genome	67	56	58	47	43	37	26	82	107
DESeq	H. sapiens	Genome	25.35	27.52	35.75	19.25	29.45	22.05	30.82	46.56	42.32
DESeq	R. aegyptiacus	Transcriptome	278.25	343.2	599.55	434.11	407.28	462.95	245.73	390.14	538.07
DESeq	R. aegyptiacus	Genome	449.46	614.24	796.67	447.33	554.72	650.09	321.62	524.93	741.46

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	25.35	19.25	30.82	-0.4	0.28	0.68
7h	27.52	29.45	46.56	0.1	0.76	0.66
23h	35.75	22.05	42.32	-0.7	0.24	0.94

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	25.35	27.52	35.75	0.12	0.5	0.38
Ebov	19.25	29.45	22.05	0.61	0.2	-0.42
Marv	30.82	46.56	42.32	0.6	0.46	-0.14

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	278.25	434.11	245.73	0.64	-0.18	-0.82
7h	343.2	407.28	390.14	0.25	0.18	-0.06
23h	599.55	462.95	538.07	-0.37	-0.16	0.22

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	278.25	343.2	599.55	0.3	1.11	0.8
Ebov	434.11	407.28	462.95	-0.09	0.09	0.18
Marv	245.73	390.14	538.07	0.67	1.13	0.46

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material