SIGIRR
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| SIGIRR | TIR8 | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | NM_021805 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
This gene is only lowly expressed.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 5 | 8 | 5 | 7 | 6 | 10 | 8 | 11 | 5 |
Read_Max |  | R. aegyptiacus | Transcriptome | 33 | 32 | 42 | 37 | 29 | 43 | 38 | 48 | 55 |
Read_Max |  | R. aegyptiacus | Genome | 38 | 37 | 35 | 46 | 25 | 27 | 33 | 58 | 61 |
DESeq | | H. sapiens | Genome | 29.41 | 29.56 | 17.88 | 31.8 | 24.58 | 27.32 | 25.56 | 16.99 | 26.01 |
DESeq | | R. aegyptiacus | Transcriptome | 201.79 | 187.08 | 205.0 | 174.98 | 209.07 | 238.39 | 209.02 | 212.51 | 324.64 |
DESeq | | R. aegyptiacus | Genome | 292.19 | 274.72 | 300.14 | 317.97 | 302.47 | 334.18 | 266.51 | 311.63 | 461.49 |