SIGIRR

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SIGIRR TIR8 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain NM_021805 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

This gene is only lowly expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome5 8 5 7 6 10 8 11 5
Read_Max
batR. aegyptiacusTranscriptome 33 32 42 37 29 43 38 48 55
Read_Max
bat_genomeR. aegyptiacusGenome 38 37 35 46 25 27 33 58 61
DESeq
humanH. sapiensGenome 29.41 29.56 17.88 31.8 24.58 27.32 25.56 16.99 26.01
DESeq
batR. aegyptiacusTranscriptome 201.79 187.08 205.0 174.98 209.07 238.39 209.02 212.51 324.64
DESeq
bat_genomeR. aegyptiacusGenome 292.19 274.72 300.14 317.97 302.47 334.18 266.51 311.63 461.49

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 29.41 31.8 25.56 0.11 -0.2 -0.32
7h 29.56 24.58 16.99 -0.27 -0.8 -0.53
23h 17.88 27.32 26.01 0.61 0.54 -0.07

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 29.41 29.56 17.88 0.01 -0.72 -0.73
Ebov 31.8 24.58 27.32 -0.37 -0.22 0.15
Marv 25.56 16.99 26.01 -0.59 0.03 0.61

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 201.79 174.98 209.02 -0.21 0.05 0.26
7h 187.08 209.07 212.51 0.16 0.18 0.02
23h 205.0 238.39 324.64 0.22 0.66 0.45

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 201.79 187.08 205.0 -0.11 0.02 0.13
Ebov 174.98 209.07 238.39 0.26 0.45 0.19
Marv 209.02 212.51 324.64 0.02 0.64 0.61