PTPN6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PTPN6 HCPH, HPTP1C, SHP1,HCP, HCPH, PTP-1C, SHP-1 protein tyrosine phosphatase, non-receptor type 6 NM_002831 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

This gene was only found in human cells and shows only a very weak expression ($<$20 reads). There is no difference between the different probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome18 19 16 19 20 10 21 26 17
Read_Max
batR. aegyptiacusTranscriptome NA NA 2 NA NA 1 NA 2 1
Read_Max
bat_genomeR. aegyptiacusGenome 2 2 2 1 1 1 1 4 5
DESeq
humanH. sapiensGenome 188.74 216.19 201.55 160.7 197.73 51.01 158.9 221.62 204.33
DESeq
batR. aegyptiacusTranscriptome 1.0 1.0 3.44 1.0 1.0 3.57 1.0 2.65 1.87
DESeq
bat_genomeR. aegyptiacusGenome 5.16 10.04 15.62 0.99 5.58 3.92 1.12 11.1 19.69

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 188.74 160.7 158.9 -0.23 -0.25 -0.02
7h 216.19 197.73 221.62 -0.13 0.04 0.16
23h 201.55 51.01 204.33 -1.98 0.02 2.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 188.74 216.19 201.55 0.2 0.09 -0.1
Ebov 160.7 197.73 51.01 0.3 -1.66 -1.95
Marv 158.9 221.62 204.33 0.48 0.36 -0.12

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 1.0 0.0 0.0 0.0
7h 1.0 1.0 2.65 0.0 1.41 1.41
23h 3.44 3.57 1.87 0.05 -0.88 -0.93

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 3.44 0.0 1.78 1.78
Ebov 1.0 1.0 3.57 0.0 1.84 1.84
Marv 1.0 2.65 1.87 1.41 0.9 -0.5