EDEM2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
EDEM2	C20orf31, C20orf49, bA4204.1,FLJ10783	ER degradation enhancer, mannosidase alpha-like 2	NM_018217	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins~\citemast05human.

Low expression in human cells, but significant expression in bat cells. Looks upregulated in Marburg-infected cells in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	64	80	70	109	87	97	105	90	79
Read_Max	R. aegyptiacus	Transcriptome	325	356	218	285	254	201	192	361	320
Read_Max	R. aegyptiacus	Genome	342	275	179	325	200	103	156	425	345
DESeq	H. sapiens	Genome	734.69	730.21	674.14	716.21	679.0	615.54	729.96	677.25	778.45
DESeq	R. aegyptiacus	Transcriptome	1950.13	2075.07	2048.3	1884.53	1927.26	1569.05	1848.71	1934.33	2036.45
DESeq	R. aegyptiacus	Genome	2030.74	1973.22	2038.53	2260.35	2021.32	1631.76	1967.93	2053.73	2022.32

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	734.69	716.21	729.96	-0.04	-0.01	0.03
7h	730.21	679.0	677.25	-0.1	-0.11	-0.0
23h	674.14	615.54	778.45	-0.13	0.21	0.34

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	734.69	730.21	674.14	-0.01	-0.12	-0.12
Ebov	716.21	679.0	615.54	-0.08	-0.22	-0.14
Marv	729.96	677.25	778.45	-0.11	0.09	0.2

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1950.13	1884.53	1848.71	-0.05	-0.08	-0.03
7h	2075.07	1927.26	1934.33	-0.11	-0.1	0.01
23h	2048.3	1569.05	2036.45	-0.38	-0.01	0.38

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1950.13	2075.07	2048.3	0.09	0.07	-0.02
Ebov	1884.53	1927.26	1569.05	0.03	-0.26	-0.3
Marv	1848.71	1934.33	2036.45	0.07	0.14	0.07

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material