Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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STAT2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
STAT2	STAT2, ISGF-3, P113, STAT113,STAT113	signal transducer and activator of transcription 2, 113kDa	NM_005419	pdf

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Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

This gene is expressed in all probes in human cells and bat cells. It tends to be upregulated in the infected and non-infected probes after 7 h in human cells, but downregulated in bat cells. The exception is the the Marburg infected bat cells probe, where it is also upregulated after 7h.

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