IL6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
IL6 BSF2, HGF, HSF, IFNB2, IL-6,IL-6, BSF2 interleukin 6 NM_000600 pdf NONE NONE NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

Expression levels are not available in human cells. %%%%%%%%%%%%%%%%%%%%%

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome0 0 0 0 0 0 2 2 1
Read_Max
batR. aegyptiacusTranscriptome 52 55 82 47 32 51 45 71 81
Read_Max
bat_genomeR. aegyptiacusGenome 77 51 81 59 29 28 45 82 98
DESeq
humanH. sapiensGenome 1.0 1.0 1.0 1.0 1.0 1.0 2.75 3.4 4.26
DESeq
batR. aegyptiacusTranscriptome 164.83 197.06 373.57 155.75 136.79 152.42 190.11 204.25 272.16
DESeq
bat_genomeR. aegyptiacusGenome 391.88 309.4 804.48 386.11 292.43 340.71 366.6 406.78 528.27

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 2.75 0.0 1.46 1.46
7h 1.0 1.0 3.4 0.0 1.77 1.77
23h 1.0 1.0 4.26 0.0 2.09 2.09

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.0 1.0 0.0 0.0 0.0
Ebov 1.0 1.0 1.0 0.0 0.0 0.0
Marv 2.75 3.4 4.26 0.31 0.63 0.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 164.83 155.75 190.11 -0.08 0.21 0.29
7h 197.06 136.79 204.25 -0.53 0.05 0.58
23h 373.57 152.42 272.16 -1.29 -0.46 0.84

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 164.83 197.06 373.57 0.26 1.18 0.92
Ebov 155.75 136.79 152.42 -0.19 -0.03 0.16
Marv 190.11 204.25 272.16 0.1 0.52 0.41