TLR3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TLR3 CD283, IIAE2 toll-like receptor 3 pdf NONE

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Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

For TLR3 there was no expression in human cells, but good expression profile visible in bat cells; perhaps upregulated in Ebola and Marburg infected cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2 1 1 0 2 0 2 4 2
Read_Max
batR. aegyptiacusTranscriptome 67 60 94 119 119 97 86 135 155
Read_Max
bat_genomeR. aegyptiacusGenome 76 128 81 59 97 58 73 169 176
DESeq
humanH. sapiensGenome 8.1 4.06 2.99 1.0 4.25 1.0 4.51 7.39 8.61
DESeq
batR. aegyptiacusTranscriptome 600.86 572.84 803.55 1032.96 1148.65 831.22 841.98 1065.98 1077.77
DESeq
bat_genomeR. aegyptiacusGenome 709.0 1108.91 800.01 693.21 1200.96 966.0 899.63 1144.22 1125.89

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8.1 1.0 4.51 -3.02 -0.84 2.17
7h 4.06 4.25 7.39 0.07 0.86 0.8
23h 2.99 1.0 8.61 -1.58 1.53 3.11

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8.1 4.06 2.99 -1.0 -1.44 -0.44
Ebov 1.0 4.25 1.0 2.09 0.0 -2.09
Marv 4.51 7.39 8.61 0.71 0.93 0.22

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 600.86 1032.96 841.98 0.78 0.49 -0.29
7h 572.84 1148.65 1065.98 1.0 0.9 -0.11
23h 803.55 831.22 1077.77 0.05 0.42 0.37

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 600.86 572.84 803.55 -0.07 0.42 0.49
Ebov 1032.96 1148.65 831.22 0.15 -0.31 -0.47
Marv 841.98 1065.98 1077.77 0.34 0.36 0.02