DDX58

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DDX58	AK301678, F5H5W6, RIG-I,RIG-I, FLJ13599, DKFZp434J1111	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	NM_014314	pdf

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Description

Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58), mRNA. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response.

Very low expression in human cells and bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	9	10	9	10	15	11	10	20	16
Read_Max	R. aegyptiacus	Transcriptome	8	4	7	6	8	4	3	11	6
Read_Max	R. aegyptiacus	Genome	9	5	7	4	3	3	3	9	7
DESeq	H. sapiens	Genome	170.47	167.24	171.77	170.96	173.35	164.17	163.28	135.29	240.22
DESeq	R. aegyptiacus	Transcriptome	22.0	18.25	51.08	27.55	26.19	21.53	11.01	25.79	39.49
DESeq	R. aegyptiacus	Genome	44.69	37.42	60.25	25.67	23.44	37.86	25.86	28.55	56.51

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	170.47	170.96	163.28	0.0	-0.06	-0.07
7h	167.24	173.35	135.29	0.05	-0.31	-0.36
23h	171.77	164.17	240.22	-0.07	0.48	0.55

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	170.47	167.24	171.77	-0.03	0.01	0.04
Ebov	170.96	173.35	164.17	0.02	-0.06	-0.08
Marv	163.28	135.29	240.22	-0.27	0.56	0.83

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	22.0	27.55	11.01	0.32	-1.0	-1.32
7h	18.25	26.19	25.79	0.52	0.5	-0.02
23h	51.08	21.53	39.49	-1.25	-0.37	0.88

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	22.0	18.25	51.08	-0.27	1.22	1.48
Ebov	27.55	26.19	21.53	-0.07	-0.36	-0.28
Marv	11.01	25.79	39.49	1.23	1.84	0.61

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material