IRF8
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| IRF8 | IRF-8, ICSBP | interferon regulatory factor 8 | NM_002163 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.
The expression is very low in general (< 10 reads), but there is no expression at all in the Ebola and Marburg infected probes after 23 h.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 8 | 13 | 9 | 10 | 15 | 3 | 11 | 9 | 3 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 2 | 0 | 0 | 1 | 0 | 2 | 0 | 1 | 2 |
DESeq | | H. sapiens | Genome | 80.15 | 109.11 | 78.44 | 85.41 | 74.17 | 16.79 | 101.88 | 73.74 | 15.14 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 1.72 | 0.0 | 0.0 | 0.99 | 0.0 | 6.53 | 0.0 | 1.59 | 7.71 |