RELB
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| RELB | Q01201, Q6GTX7, Q9UEI7,REL-B | v-rel avian reticuloendotheliosis viral oncogene homolog B |  |
 |
 |
 |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Homo sapiens v-rel reticuloendotheliosis viral oncogene homolog B (RELB), mRNA. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.
About 5 times increase in expression at 23 h after Ebola infection in human cells cells. Some support of increased expression in infected bat cells cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 14 | 18 | 17 | 18 | 29 | 284 | 21 | 17 | 31 |
Read_Max |  | R. aegyptiacus | Transcriptome | 35 | 29 | 40 | 16 | 15 | 65 | 17 | 15 | 50 |
Read_Max |  | R. aegyptiacus | Genome | 31 | 15 | 25 | 26 | 11 | 33 | 15 | 23 | 51 |
DESeq | | H. sapiens | Genome | 179.6 | 168.26 | 153.89 | 210.89 | 170.09 | 3001.3 | 198.37 | 180.85 | 430.5 |
DESeq | | R. aegyptiacus | Transcriptome | 187.51 | 188.89 | 340.59 | 117.29 | 131.32 | 441.13 | 126.7 | 84.45 | 265.16 |
DESeq | | R. aegyptiacus | Genome | 292.19 | 209.92 | 581.32 | 335.74 | 229.92 | 646.18 | 233.9 | 190.31 | 449.5 |