MAPK10

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAPK10	JNK3, p493F12, p54bSAPK, PRKM10	mitogen-activated protein kinase 10		pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

It is not expressed in the investigated human cells and bat cells probes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	23	22	23	20	29	24	35	25	43
Read_Max	R. aegyptiacus	Transcriptome	199	184	112	174	152	194	156	191	147
Read_Max	R. aegyptiacus	Genome	1	2	2	2	2	2	2	3	2
DESeq	H. sapiens	Genome	8.1	3.04	4.97	15.83	14.82	6.26	6.26	11.39	7.52
DESeq	R. aegyptiacus	Transcriptome	836.1	802.49	666.74	869.05	812.46	1012.15	879.8	851.17	639.54
DESeq	R. aegyptiacus	Genome	0.86	9.13	16.74	2.96	11.16	13.05	7.87	10.31	12.84

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8.1	15.83	6.26	0.97	-0.37	-1.34
7h	3.04	14.82	11.39	2.29	1.91	-0.38
23h	4.97	6.26	7.52	0.33	0.6	0.26

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8.1	3.04	4.97	-1.41	-0.7	0.71
Ebov	15.83	14.82	6.26	-0.1	-1.34	-1.24
Marv	6.26	11.39	7.52	0.86	0.26	-0.6

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	836.1	869.05	879.8	0.06	0.07	0.02
7h	802.49	812.46	851.17	0.02	0.08	0.07
23h	666.74	1012.15	639.54	0.6	-0.06	-0.66

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	836.1	802.49	666.74	-0.06	-0.33	-0.27
Ebov	869.05	812.46	1012.15	-0.1	0.22	0.32
Marv	879.8	851.17	639.54	-0.05	-0.46	-0.41

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material