MAPK10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAPK10 JNK3, p493F12, p54bSAPK, PRKM10 mitogen-activated protein kinase 10 pdf NONE

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Description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

It is not expressed in the investigated human cells and bat cells probes.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome23 22 23 20 29 24 35 25 43
Read_Max
batR. aegyptiacusTranscriptome 199 184 112 174 152 194 156 191 147
Read_Max
bat_genomeR. aegyptiacusGenome 1 2 2 2 2 2 2 3 2
DESeq
humanH. sapiensGenome 8.1 3.04 4.97 15.83 14.82 6.26 6.26 11.39 7.52
DESeq
batR. aegyptiacusTranscriptome 836.1 802.49 666.74 869.05 812.46 1012.15 879.8 851.17 639.54
DESeq
bat_genomeR. aegyptiacusGenome 0.86 9.13 16.74 2.96 11.16 13.05 7.87 10.31 12.84

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8.1 15.83 6.26 0.97 -0.37 -1.34
7h 3.04 14.82 11.39 2.29 1.91 -0.38
23h 4.97 6.26 7.52 0.33 0.6 0.26

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8.1 3.04 4.97 -1.41 -0.7 0.71
Ebov 15.83 14.82 6.26 -0.1 -1.34 -1.24
Marv 6.26 11.39 7.52 0.86 0.26 -0.6

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 836.1 869.05 879.8 0.06 0.07 0.02
7h 802.49 812.46 851.17 0.02 0.08 0.07
23h 666.74 1012.15 639.54 0.6 -0.06 -0.66

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 836.1 802.49 666.74 -0.06 -0.33 -0.27
Ebov 869.05 812.46 1012.15 -0.1 0.22 0.32
Marv 879.8 851.17 639.54 -0.05 -0.46 -0.41