NQO1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NQO1	NAD(P)H Dehydrogenase, Quinone 1, NMOR1,DHQU, QR1, DTD	NAD(P)H dehydrogenase, quinone 1		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

The gene NQO1 is significantly downregulated in Ebola infected cells in human cells from 7 h to 23 h after infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	2631	2629	3021	2765	3880	1223	3491	4230	5235
Read_Max	R. aegyptiacus	Transcriptome	24	21	49	22	15	19	16	28	40
Read_Max	R. aegyptiacus	Genome	35	22	35	22	19	11	21	42	47
DESeq	H. sapiens	Genome	25741.07	20820.69	22759.52	24356.87	21436.89	6159.52	24633.79	24300.45	44080.95
DESeq	R. aegyptiacus	Transcriptome	69.89	94.49	207.44	87.99	73.28	93.39	76.64	82.79	180.32
DESeq	R. aegyptiacus	Genome	95.39	105.87	232.08	105.66	119.43	127.93	95.59	115.77	222.61

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	25741.07	24356.87	24633.79	-0.08	-0.06	0.02
7h	20820.69	21436.89	24300.45	0.04	0.22	0.18
23h	22759.52	6159.52	44080.95	-1.89	0.95	2.84

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	25741.07	20820.69	22759.52	-0.31	-0.18	0.13
Ebov	24356.87	21436.89	6159.52	-0.18	-1.98	-1.8
Marv	24633.79	24300.45	44080.95	-0.02	0.84	0.86

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	69.89	87.99	76.64	0.33	0.13	-0.2
7h	94.49	73.28	82.79	-0.37	-0.19	0.18
23h	207.44	93.39	180.32	-1.15	-0.2	0.95

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	69.89	94.49	207.44	0.44	1.57	1.13
Ebov	87.99	73.28	93.39	-0.26	0.09	0.35
Marv	76.64	82.79	180.32	0.11	1.23	1.12

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material