NQO1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NQO1 NAD(P)H Dehydrogenase, Quinone 1, NMOR1,DHQU, QR1, DTD NAD(P)H dehydrogenase, quinone 1 pdf

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Description

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

The gene NQO1 is significantly downregulated in Ebola infected cells in human cells from 7 h to 23 h after infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome2631 2629 3021 2765 3880 1223 3491 4230 5235
Read_Max
batR. aegyptiacusTranscriptome 24 21 49 22 15 19 16 28 40
Read_Max
bat_genomeR. aegyptiacusGenome 35 22 35 22 19 11 21 42 47
DESeq
humanH. sapiensGenome 25741.07 20820.69 22759.52 24356.87 21436.89 6159.52 24633.79 24300.45 44080.95
DESeq
batR. aegyptiacusTranscriptome 69.89 94.49 207.44 87.99 73.28 93.39 76.64 82.79 180.32
DESeq
bat_genomeR. aegyptiacusGenome 95.39 105.87 232.08 105.66 119.43 127.93 95.59 115.77 222.61

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 25741.07 24356.87 24633.79 -0.08 -0.06 0.02
7h 20820.69 21436.89 24300.45 0.04 0.22 0.18
23h 22759.52 6159.52 44080.95 -1.89 0.95 2.84

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 25741.07 20820.69 22759.52 -0.31 -0.18 0.13
Ebov 24356.87 21436.89 6159.52 -0.18 -1.98 -1.8
Marv 24633.79 24300.45 44080.95 -0.02 0.84 0.86

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 69.89 87.99 76.64 0.33 0.13 -0.2
7h 94.49 73.28 82.79 -0.37 -0.19 0.18
23h 207.44 93.39 180.32 -1.15 -0.2 0.95

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 69.89 94.49 207.44 0.44 1.57 1.13
Ebov 87.99 73.28 93.39 -0.26 0.09 0.35
Marv 76.64 82.79 180.32 0.11 1.23 1.12