Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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MAPK9

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
MAPK9	PRKM9, JNK2,JNK2, p54a, SAPK	mitogen-activated protein kinase 9		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens mitogen-activated protein kinase 9 (MAPK9), Member of the MAP kinase family. Mediates immediate-early gene expression in response to various cell stimuli, related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.

This gene is expressed across all samples. Interestingly, there is a drop in expression in all non-mock human cells 23 h samples. This might be relevant, as MAPK9/JNK2 promotes cell survival. See also Raciti et al.~\cite{raciti12jnk2.

\igvfigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00220/snapshots//hg19.goi.00220_igv.eps % \caption\igv of gene MAPK9. % <- say something about the figure here \endfigure }

\sashimifigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00220/snapshots//hg19.goi.00220_sashimi.eps % \caption\sashimi of gene MAPK9. % <- say something about the figure here \endfigure }

\ucscfigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00220/snapshots//hg19.goi.00220_ucsc.eps % \caption\ucsc of gene MAPK9. % <- say something about the figure here \endfigure }

\setcounterfigure0\enddocument

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source		Species	Mapping on	Mock3h	Mock7h	Mock23h	EBOV3h	EBOV7h	EBOV23h	MARV3h	MARV7h	MARV23h
Read_Max		H. sapiens	Genome	234	261	193	215	235	109	281	345	144
Read_Max		R. aegyptiacus	Transcriptome	151	145	118	130	129	166	137	167	185
Read_Max		R. aegyptiacus	Genome	162	149	115	149	111	104	131	231	237
DESeq		H. sapiens	Genome	2191.92	2231.46	2425.48	2248.15	2344.74	1112.95	2386.12	2088.1	1817.96
DESeq		R. aegyptiacus	Transcriptome	968.84	889.63	935.48	1057.68	988.77	1184.09	1031.09	1013.11	1017.41
DESeq		R. aegyptiacus	Genome	1680.97	1830.85	1662.51	1506.9	1641.83	1840.63	1730.65	1695.32	1753.48

Human Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	2191.92	2248.15	2386.12	0.04	0.12	0.09
7h	2231.46	2344.74	2088.1	0.07	-0.1	-0.17
23h	2425.48	1112.95	1817.96	-1.12	-0.42	0.71

Human Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	2191.92	2231.46	2425.48	0.03	0.15	0.12
Ebov	2248.15	2344.74	1112.95	0.06	-1.01	-1.08
Marv	2386.12	2088.1	1817.96	-0.19	-0.39	-0.2

Bat Condition Comparisons

	Mock	EBOV	MARV	FCMock_EBOV	FCMock_MARV	FCEBOV_MARV
3h	968.84	1057.68	1031.09	0.13	0.09	-0.04
7h	889.63	988.77	1013.11	0.15	0.19	0.04
23h	935.48	1184.09	1017.41	0.34	0.12	-0.22

Bat Time Point Comparisons

	3h	7h	23h	FC3h_7h	FC3h_23h	FC7h_23h
Mock	968.84	889.63	935.48	-0.12	-0.05	0.07
Ebov	1057.68	988.77	1184.09	-0.1	0.16	0.26
Marv	1031.09	1013.11	1017.41	-0.03	-0.02	0.01