MAPK9

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAPK9 PRKM9, JNK2,JNK2, p54a, SAPK mitogen-activated protein kinase 9 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens mitogen-activated protein kinase 9 (MAPK9), Member of the MAP kinase family. Mediates immediate-early gene expression in response to various cell stimuli, related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells.

This gene is expressed across all samples. Interestingly, there is a drop in expression in all non-mock human cells 23 h samples. This might be relevant, as MAPK9/JNK2 promotes cell survival. See also Raciti et al.~\cite{raciti12jnk2.

\igvfigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00220/snapshots//hg19.goi.00220_igv.eps % \caption\igv of gene MAPK9. % <- say something about the figure here \endfigure }

\sashimifigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00220/snapshots//hg19.goi.00220_sashimi.eps % \caption\sashimi of gene MAPK9. % <- say something about the figure here \endfigure }

\ucscfigure{ \beginfigure[H] \centering \includegraphics[width=\textwidth]../../input/holy_folders/hg19.goi.00220/snapshots//hg19.goi.00220_ucsc.eps % \caption\ucsc of gene MAPK9. % <- say something about the figure here \endfigure }

\setcounterfigure0\enddocument

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome234 261 193 215 235 109 281 345 144
Read_Max
batR. aegyptiacusTranscriptome 151 145 118 130 129 166 137 167 185
Read_Max
bat_genomeR. aegyptiacusGenome 162 149 115 149 111 104 131 231 237
DESeq
humanH. sapiensGenome 2191.92 2231.46 2425.48 2248.15 2344.74 1112.95 2386.12 2088.1 1817.96
DESeq
batR. aegyptiacusTranscriptome 968.84 889.63 935.48 1057.68 988.77 1184.09 1031.09 1013.11 1017.41
DESeq
bat_genomeR. aegyptiacusGenome 1680.97 1830.85 1662.51 1506.9 1641.83 1840.63 1730.65 1695.32 1753.48

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2191.92 2248.15 2386.12 0.04 0.12 0.09
7h 2231.46 2344.74 2088.1 0.07 -0.1 -0.17
23h 2425.48 1112.95 1817.96 -1.12 -0.42 0.71

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2191.92 2231.46 2425.48 0.03 0.15 0.12
Ebov 2248.15 2344.74 1112.95 0.06 -1.01 -1.08
Marv 2386.12 2088.1 1817.96 -0.19 -0.39 -0.2

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 968.84 1057.68 1031.09 0.13 0.09 -0.04
7h 889.63 988.77 1013.11 0.15 0.19 0.04
23h 935.48 1184.09 1017.41 0.34 0.12 -0.22

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 968.84 889.63 935.48 -0.12 -0.05 0.07
Ebov 1057.68 988.77 1184.09 -0.1 0.16 0.26
Marv 1031.09 1013.11 1017.41 -0.03 -0.02 0.01