SP110

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SP110 SP110 nuclear body protein NM_080424 pdf

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Description

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.

The gene is slightly expressed in human cells regardless of the infectious state. In contrast, the gene could not be detected in the transcriptome of bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome9 15 11 7 12 8 15 17 10
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 17 25 30 19 13 18 11 21 37
DESeq
humanH. sapiensGenome 86.24 98.91 101.28 85.41 94.49 37.85 99.25 132.89 91.25
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 101.41 154.24 273.37 131.34 128.36 198.42 110.2 145.9 263.71

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 86.24 85.41 99.25 -0.01 0.2 0.22
7h 98.91 94.49 132.89 -0.07 0.43 0.49
23h 101.28 37.85 91.25 -1.42 -0.15 1.27

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 86.24 98.91 101.28 0.2 0.23 0.03
Ebov 85.41 94.49 37.85 0.15 -1.17 -1.32
Marv 99.25 132.89 91.25 0.42 -0.12 -0.54

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA