ZC3HAV1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ZC3HAV1	A4D1R2, A4D1S4, PRO1677, Q7Z2W4, Q8IW57, Q8TAJ3, Q96N79, Q9H8R9, Q9P0Y7, ZC3HDC2, ZAP,ZAP, FLB6421, FLJ13288, MGC48898, ZC3H2, PARP13	zinc finger CCCH-type, antiviral 1	NM_020119	pdf				NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens zinc finger CCCH-type, antiviral 1 (ZC3HAV1), transcript variant 1, mRNA. This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.

Two times up- and down-regulation in human cells at 7 h and 23 h after Ebola infection, respectively. Consistent up- and down-regulation in Marburg infected human cells cells, but at lower rate. Subset of human cells exons map well to bat cells with decent expression. Marburg infected bat cells shows increase of expression.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	161	126	136	88	164	80	111	148	126
Read_Max	R. aegyptiacus	Transcriptome	64	59	48	47	49	51	42	65	67
Read_Max	R. aegyptiacus	Genome	NA	NA	NA	NA	NA	NA	NA	NA	NA
DESeq	H. sapiens	Genome	3574.06	3061.64	3918.69	2446.62	3197.52	1826.18	2340.51	2875.46	4039.41
DESeq	R. aegyptiacus	Transcriptome	779.81	651.81	700.94	703.32	707.33	800.42	679.57	675.19	794.36
DESeq	R. aegyptiacus	Genome	NA	NA	NA	NA	NA	NA	NA	NA	NA

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3574.06	2446.62	2340.51	-0.55	-0.61	-0.06
7h	3061.64	3197.52	2875.46	0.06	-0.09	-0.15
23h	3918.69	1826.18	4039.41	-1.1	0.04	1.15

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3574.06	3061.64	3918.69	-0.22	0.13	0.36
Ebov	2446.62	3197.52	1826.18	0.39	-0.42	-0.81
Marv	2340.51	2875.46	4039.41	0.3	0.79	0.49

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	779.81	703.32	679.57	-0.15	-0.2	-0.05
7h	651.81	707.33	675.19	0.12	0.05	-0.07
23h	700.94	800.42	794.36	0.19	0.18	-0.01

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	779.81	651.81	700.94	-0.26	-0.15	0.1
Ebov	703.32	707.33	800.42	0.01	0.19	0.18
Marv	679.57	675.19	794.36	-0.01	0.23	0.23

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material