ZC3HAV1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ZC3HAV1 A4D1R2, A4D1S4, PRO1677, Q7Z2W4, Q8IW57, Q8TAJ3, Q96N79, Q9H8R9, Q9P0Y7, ZC3HDC2, ZAP,ZAP, FLB6421, FLJ13288, MGC48898, ZC3H2, PARP13 zinc finger CCCH-type, antiviral 1 NM_020119 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens zinc finger CCCH-type, antiviral 1 (ZC3HAV1), transcript variant 1, mRNA. This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.

Two times up- and down-regulation in human cells at 7 h and 23 h after Ebola infection, respectively. Consistent up- and down-regulation in Marburg infected human cells cells, but at lower rate. Subset of human cells exons map well to bat cells with decent expression. Marburg infected bat cells shows increase of expression.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome161 126 136 88 164 80 111 148 126
Read_Max
batR. aegyptiacusTranscriptome 64 59 48 47 49 51 42 65 67
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 3574.06 3061.64 3918.69 2446.62 3197.52 1826.18 2340.51 2875.46 4039.41
DESeq
batR. aegyptiacusTranscriptome 779.81 651.81 700.94 703.32 707.33 800.42 679.57 675.19 794.36
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3574.06 2446.62 2340.51 -0.55 -0.61 -0.06
7h 3061.64 3197.52 2875.46 0.06 -0.09 -0.15
23h 3918.69 1826.18 4039.41 -1.1 0.04 1.15

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3574.06 3061.64 3918.69 -0.22 0.13 0.36
Ebov 2446.62 3197.52 1826.18 0.39 -0.42 -0.81
Marv 2340.51 2875.46 4039.41 0.3 0.79 0.49

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 779.81 703.32 679.57 -0.15 -0.2 -0.05
7h 651.81 707.33 675.19 0.12 0.05 -0.07
23h 700.94 800.42 794.36 0.19 0.18 -0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 779.81 651.81 700.94 -0.26 -0.15 0.1
Ebov 703.32 707.33 800.42 0.01 0.19 0.18
Marv 679.57 675.19 794.36 -0.01 0.23 0.23