TRAF3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TRAF3 CAP-1, CD40bp, CRAF1, LAP1 TNF receptor-associated factor 3 NM_145725 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.

It is constantly expressed in both human cells and bat cells under all investigated conditions.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome66 56 65 61 101 122 71 86 72
Read_Max
batR. aegyptiacusTranscriptome 163 158 78 126 125 199 145 154 159
Read_Max
bat_genomeR. aegyptiacusGenome 182 127 73 151 103 113 132 190 183
DESeq
humanH. sapiensGenome 1552.61 1587.92 1403.86 1720.01 1574.06 2307.81 1623.83 1563.73 1849.49
DESeq
batR. aegyptiacusTranscriptome 1648.52 1652.09 1051.52 1320.48 1664.44 1838.52 1704.09 1484.87 1567.6
DESeq
bat_genomeR. aegyptiacusGenome 2798.17 2317.31 2044.1 2766.93 2624.03 3083.38 2922.66 2489.06 2660.19

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1552.61 1720.01 1623.83 0.15 0.06 -0.08
7h 1587.92 1574.06 1563.73 -0.01 -0.02 -0.01
23h 1403.86 2307.81 1849.49 0.72 0.4 -0.32

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1552.61 1587.92 1403.86 0.03 -0.15 -0.18
Ebov 1720.01 1574.06 2307.81 -0.13 0.42 0.55
Marv 1623.83 1563.73 1849.49 -0.05 0.19 0.24

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1648.52 1320.48 1704.09 -0.32 0.05 0.37
7h 1652.09 1664.44 1484.87 0.01 -0.15 -0.16
23h 1051.52 1838.52 1567.6 0.81 0.58 -0.23

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1648.52 1652.09 1051.52 0.0 -0.65 -0.65
Ebov 1320.48 1664.44 1838.52 0.33 0.48 0.14
Marv 1704.09 1484.87 1567.6 -0.2 -0.12 0.08