TRAF3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TRAF3	CAP-1, CD40bp, CRAF1, LAP1	TNF receptor-associated factor 3	NM_145725	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.

It is constantly expressed in both human cells and bat cells under all investigated conditions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	66	56	65	61	101	122	71	86	72
Read_Max	R. aegyptiacus	Transcriptome	163	158	78	126	125	199	145	154	159
Read_Max	R. aegyptiacus	Genome	182	127	73	151	103	113	132	190	183
DESeq	H. sapiens	Genome	1552.61	1587.92	1403.86	1720.01	1574.06	2307.81	1623.83	1563.73	1849.49
DESeq	R. aegyptiacus	Transcriptome	1648.52	1652.09	1051.52	1320.48	1664.44	1838.52	1704.09	1484.87	1567.6
DESeq	R. aegyptiacus	Genome	2798.17	2317.31	2044.1	2766.93	2624.03	3083.38	2922.66	2489.06	2660.19

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1552.61	1720.01	1623.83	0.15	0.06	-0.08
7h	1587.92	1574.06	1563.73	-0.01	-0.02	-0.01
23h	1403.86	2307.81	1849.49	0.72	0.4	-0.32

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1552.61	1587.92	1403.86	0.03	-0.15	-0.18
Ebov	1720.01	1574.06	2307.81	-0.13	0.42	0.55
Marv	1623.83	1563.73	1849.49	-0.05	0.19	0.24

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1648.52	1320.48	1704.09	-0.32	0.05	0.37
7h	1652.09	1664.44	1484.87	0.01	-0.15	-0.16
23h	1051.52	1838.52	1567.6	0.81	0.58	-0.23

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1648.52	1652.09	1051.52	0.0	-0.65	-0.65
Ebov	1320.48	1664.44	1838.52	0.33	0.48	0.14
Marv	1704.09	1484.87	1567.6	-0.2	-0.12	0.08

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material