IRF3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
IRF3	Interferon Regulatory Factor 3	interferon regulatory factor 3	NM_001571	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

The gene IRF is expressed at moderate levels throughout the datasets, there is a slight increase of expression after Ebola infection in human cells at both timepoints, whereas expression decreases again from 7 h to 23 h after Marburg virus infection. There is a slight increase in expression 23 h after Marburg virus infection in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	48	54	45	37	57	80	54	61	40
Read_Max	R. aegyptiacus	Transcriptome	53	52	49	58	50	62	57	65	96
Read_Max	R. aegyptiacus	Genome	102	100	84	78	58	54	51	96	154
DESeq	H. sapiens	Genome	420.11	587.43	568.9	458.41	394.47	578.69	493.11	622.89	538.15
DESeq	R. aegyptiacus	Transcriptome	311.85	353.18	468.85	388.33	419.32	523.25	394.79	415.76	566.94
DESeq	R. aegyptiacus	Genome	599.85	706.42	807.82	652.73	670.8	887.68	606.12	701.76	1016.3

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	420.11	458.41	493.11	0.13	0.23	0.11
7h	587.43	394.47	622.89	-0.57	0.08	0.66
23h	568.9	578.69	538.15	0.02	-0.08	-0.1

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	420.11	587.43	568.9	0.48	0.44	-0.05
Ebov	458.41	394.47	578.69	-0.22	0.34	0.55
Marv	493.11	622.89	538.15	0.34	0.13	-0.21

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	311.85	388.33	394.79	0.32	0.34	0.02
7h	353.18	419.32	415.76	0.25	0.24	-0.01
23h	468.85	523.25	566.94	0.16	0.27	0.12

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	311.85	353.18	468.85	0.18	0.59	0.41
Ebov	388.33	419.32	523.25	0.11	0.43	0.32
Marv	394.79	415.76	566.94	0.07	0.52	0.45

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material