CCL5

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CCL5	SISd, eoCP, SCYA5, RANTES, TCP228, SIS-delta, D17S136E,RANTES, SISd, MGC17164	chemokine (C-C motif) ligand 5	NM_002985	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.

For this gene, nearly no expression was observed in all samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	2	10	1	1	2	3	1	1	7
Read_Max	R. aegyptiacus	Transcriptome	NA	2	NA	2	NA	NA	NA	2	NA
Read_Max	R. aegyptiacus	Genome	2	2	0	2	2	0	0	1	2
DESeq	H. sapiens	Genome	7.09	1.0	1.0	1.0	2.63	11.53	1.0	1.8	1.0
DESeq	R. aegyptiacus	Transcriptome	1.0	2.82	1.0	2.83	1.0	1.0	1.0	2.65	1.0
DESeq	R. aegyptiacus	Genome	1.72	1.83	0.0	1.97	4.46	0.0	0.0	0.79	1.71

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7.09	1.0	1.0	-2.83	-2.83	0.0
7h	1.0	2.63	1.8	1.4	0.85	-0.55
23h	1.0	11.53	1.0	3.53	0.0	-3.53

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7.09	1.0	1.0	-2.83	-2.83	0.0
Ebov	1.0	2.63	11.53	1.4	3.53	2.13
Marv	1.0	1.8	1.0	0.85	0.0	-0.85

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1.0	2.83	1.0	1.5	0.0	-1.5
7h	2.82	1.0	2.65	-1.5	-0.09	1.41
23h	1.0	1.0	1.0	0.0	0.0	0.0

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1.0	2.82	1.0	1.5	0.0	-1.5
Ebov	2.83	1.0	1.0	-1.5	-1.5	0.0
Marv	1.0	2.65	1.0	1.41	0.0	-1.41

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material