TRAF2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TRAF2 AK298370, TRAP3, TANK,TRAP3 TNF receptor-associated factor 2 NM_021138 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens TNF receptor-associated factor 2 (TRAF2), mRNA. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Modest expression with non-annotated expression between third and fourth exon, which most likely also overlaps MIR4479. Downstream expression. In bat cells we see similar expression levels as in human cells, but based on only 3 human cells exons.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome25 40 34 40 53 93 44 54 27
Read_Max
batR. aegyptiacusTranscriptome 43 49 35 40 35 73 29 54 50
Read_Max
bat_genomeR. aegyptiacusGenome 45 46 30 52 32 45 26 67 57
DESeq
humanH. sapiensGenome 643.36 867.89 871.71 717.35 722.9 1405.09 738.73 866.7 688.2
DESeq
batR. aegyptiacusTranscriptome 299.25 380.41 371.13 366.35 354.71 601.53 302.46 381.88 380.62
DESeq
bat_genomeR. aegyptiacusGenome 606.73 706.42 691.78 652.73 625.03 926.84 544.27 667.66 723.48

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 643.36 717.35 738.73 0.16 0.2 0.04
7h 867.89 722.9 866.7 -0.26 -0.0 0.26
23h 871.71 1405.09 688.2 0.69 -0.34 -1.03

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 643.36 867.89 871.71 0.43 0.44 0.01
Ebov 717.35 722.9 1405.09 0.01 0.97 0.96
Marv 738.73 866.7 688.2 0.23 -0.1 -0.33

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 299.25 366.35 302.46 0.29 0.02 -0.28
7h 380.41 354.71 381.88 -0.1 0.01 0.11
23h 371.13 601.53 380.62 0.7 0.04 -0.66

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 299.25 380.41 371.13 0.35 0.31 -0.04
Ebov 366.35 354.71 601.53 -0.05 0.72 0.76
Marv 302.46 381.88 380.62 0.34 0.33 -0.0