MAPK6

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAPK6	MAPK6, ERK3, HsT17250, PRKM6, p97MAPK,ERK3	mitogen-activated protein kinase 6	NM_002748	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

MAPK6 shows strong induction in Ebola virus infected human cells cells at 7 h post infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	467	405	509	394	727	396	480	559	505
Read_Max	R. aegyptiacus	Transcriptome	719	604	466	540	581	803	580	828	873
Read_Max	R. aegyptiacus	Genome	824	802	465	693	547	466	580	957	960
DESeq	H. sapiens	Genome	8445.04	7745.91	8016.07	8070.19	9019.88	7103.03	8049.35	7943.35	9341.31
DESeq	R. aegyptiacus	Transcriptome	7109.43	6330.32	6279.7	7581.82	8393.77	8543.14	8215.01	7975.56	7994.96
DESeq	R. aegyptiacus	Genome	9954.32	10735.0	8238.9	9457.13	11993.97	12086.79	12075.23	11058.42	10710.96

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	8445.04	8070.19	8049.35	-0.07	-0.07	-0.0
7h	7745.91	9019.88	7943.35	0.22	0.04	-0.18
23h	8016.07	7103.03	9341.31	-0.17	0.22	0.4

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	8445.04	7745.91	8016.07	-0.12	-0.08	0.05
Ebov	8070.19	9019.88	7103.03	0.16	-0.18	-0.34
Marv	8049.35	7943.35	9341.31	-0.02	0.21	0.23

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	7109.43	7581.82	8215.01	0.09	0.21	0.12
7h	6330.32	8393.77	7975.56	0.41	0.33	-0.07
23h	6279.7	8543.14	7994.96	0.44	0.35	-0.1

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	7109.43	6330.32	6279.7	-0.17	-0.18	-0.01
Ebov	7581.82	8393.77	8543.14	0.15	0.17	0.03
Marv	8215.01	7975.56	7994.96	-0.04	-0.04	0.0

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material