MAPK6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAPK6 MAPK6, ERK3, HsT17250, PRKM6, p97MAPK,ERK3 mitogen-activated protein kinase 6 NM_002748 pdf

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Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.

MAPK6 shows strong induction in Ebola virus infected human cells cells at 7 h post infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome467 405 509 394 727 396 480 559 505
Read_Max
batR. aegyptiacusTranscriptome 719 604 466 540 581 803 580 828 873
Read_Max
bat_genomeR. aegyptiacusGenome 824 802 465 693 547 466 580 957 960
DESeq
humanH. sapiensGenome 8445.04 7745.91 8016.07 8070.19 9019.88 7103.03 8049.35 7943.35 9341.31
DESeq
batR. aegyptiacusTranscriptome 7109.43 6330.32 6279.7 7581.82 8393.77 8543.14 8215.01 7975.56 7994.96
DESeq
bat_genomeR. aegyptiacusGenome 9954.32 10735.0 8238.9 9457.13 11993.97 12086.79 12075.23 11058.42 10710.96

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8445.04 8070.19 8049.35 -0.07 -0.07 -0.0
7h 7745.91 9019.88 7943.35 0.22 0.04 -0.18
23h 8016.07 7103.03 9341.31 -0.17 0.22 0.4

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8445.04 7745.91 8016.07 -0.12 -0.08 0.05
Ebov 8070.19 9019.88 7103.03 0.16 -0.18 -0.34
Marv 8049.35 7943.35 9341.31 -0.02 0.21 0.23

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7109.43 7581.82 8215.01 0.09 0.21 0.12
7h 6330.32 8393.77 7975.56 0.41 0.33 -0.07
23h 6279.7 8543.14 7994.96 0.44 0.35 -0.1

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7109.43 6330.32 6279.7 -0.17 -0.18 -0.01
Ebov 7581.82 8393.77 8543.14 0.15 0.17 0.03
Marv 8215.01 7975.56 7994.96 -0.04 -0.04 0.0