IFIT1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| IFIT1 | Interferon-Induced Protein With Tetratricopeptide Repeats 1, ISG56, G10P1, IFI56,GARG-16 | interferon-induced protein with tetratricopeptide repeats 1 | NM_001548 |  |
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NONE |  |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Gene shows generally strong expression in human cells. In Ebola infected cells after 23 h it is downregulated, which is interesting for a gene involved in viral defense. Weak constitutive expression in bat cells, small overlap at 3' end with IFIT5.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 5 | 4 | 8 | 3 | 5 | 3 | 9 | 6 | 5 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 5 | 5 | 2 | 3 | 5 | 1 | 4 | 5 | 6 |
DESeq | | H. sapiens | Genome | 17.24 | 15.28 | 49.65 | 12.41 | 28.64 | 3.63 | 29.07 | 15.39 | 24.92 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 13.75 | 24.64 | 2.23 | 12.84 | 17.86 | 1.31 | 12.37 | 23.0 | 17.12 |