ATP6V1B2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ATP6V1B2	HO57, VATB, VPP3, Vma2, ATP6B2, ATP6B1B2,VATB, HO57	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	NM_001693	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.

This gene is upregulated (but not several fold) in human cells in Ebola infected cells but equal in bat cells. We observed expression of 3'UTR in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	299	363	301	266	415	643	351	393	231
Read_Max	R. aegyptiacus	Transcriptome	227	239	149	226	210	269	166	279	227
Read_Max	R. aegyptiacus	Genome	261	248	136	258	191	167	159	357	252
DESeq	H. sapiens	Genome	3217.87	3482.85	3540.42	3350.05	3512.13	7230.68	3445.78	3359.07	3101.03
DESeq	R. aegyptiacus	Transcriptome	1983.73	2111.38	1898.05	2183.04	2202.13	2700.81	1822.01	2294.55	1865.88
DESeq	R. aegyptiacus	Genome	2803.33	2907.81	2517.19	3173.77	2983.43	3875.76	2777.59	3025.88	2633.65

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3217.87	3350.05	3445.78	0.06	0.1	0.04
7h	3482.85	3512.13	3359.07	0.01	-0.05	-0.06
23h	3540.42	7230.68	3101.03	1.03	-0.19	-1.22

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3217.87	3482.85	3540.42	0.11	0.14	0.02
Ebov	3350.05	3512.13	7230.68	0.07	1.11	1.04
Marv	3445.78	3359.07	3101.03	-0.04	-0.15	-0.12

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1983.73	2183.04	1822.01	0.14	-0.12	-0.26
7h	2111.38	2202.13	2294.55	0.06	0.12	0.06
23h	1898.05	2700.81	1865.88	0.51	-0.02	-0.53

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1983.73	2111.38	1898.05	0.09	-0.06	-0.15
Ebov	2183.04	2202.13	2700.81	0.01	0.31	0.29
Marv	1822.01	2294.55	1865.88	0.33	0.03	-0.3

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material