ATP6V1B2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ATP6V1B2 HO57, VATB, VPP3, Vma2, ATP6B2, ATP6B1B2,VATB, HO57 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 NM_001693 pdf

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Description

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.

This gene is upregulated (but not several fold) in human cells in Ebola infected cells but equal in bat cells. We observed expression of 3'UTR in human cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome299 363 301 266 415 643 351 393 231
Read_Max
batR. aegyptiacusTranscriptome 227 239 149 226 210 269 166 279 227
Read_Max
bat_genomeR. aegyptiacusGenome 261 248 136 258 191 167 159 357 252
DESeq
humanH. sapiensGenome 3217.87 3482.85 3540.42 3350.05 3512.13 7230.68 3445.78 3359.07 3101.03
DESeq
batR. aegyptiacusTranscriptome 1983.73 2111.38 1898.05 2183.04 2202.13 2700.81 1822.01 2294.55 1865.88
DESeq
bat_genomeR. aegyptiacusGenome 2803.33 2907.81 2517.19 3173.77 2983.43 3875.76 2777.59 3025.88 2633.65

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3217.87 3350.05 3445.78 0.06 0.1 0.04
7h 3482.85 3512.13 3359.07 0.01 -0.05 -0.06
23h 3540.42 7230.68 3101.03 1.03 -0.19 -1.22

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3217.87 3482.85 3540.42 0.11 0.14 0.02
Ebov 3350.05 3512.13 7230.68 0.07 1.11 1.04
Marv 3445.78 3359.07 3101.03 -0.04 -0.15 -0.12

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1983.73 2183.04 1822.01 0.14 -0.12 -0.26
7h 2111.38 2202.13 2294.55 0.06 0.12 0.06
23h 1898.05 2700.81 1865.88 0.51 -0.02 -0.53

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1983.73 2111.38 1898.05 0.09 -0.06 -0.15
Ebov 2183.04 2202.13 2700.81 0.01 0.31 0.29
Marv 1822.01 2294.55 1865.88 0.33 0.03 -0.3