NAPA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NAPA		N-ethylmaleimide-sensitive factor attachment protein, alpha	NM_003827	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene.

It is constantly expressed in both human cells and bat cells under all investigated conditions.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	132	191	177	154	249	318	197	266	166
Read_Max	R. aegyptiacus	Transcriptome	150	156	154	156	148	225	127	155	248
Read_Max	R. aegyptiacus	Genome	200	186	155	166	146	158	134	257	312
DESeq	H. sapiens	Genome	1114.22	1247.28	1128.85	1337.88	1340.74	2601.26	1336.11	1387.07	1178.6
DESeq	R. aegyptiacus	Transcriptome	807.53	853.32	1005.1	769.25	877.07	1284.18	908.72	835.47	1084.76
DESeq	R. aegyptiacus	Genome	1466.98	1413.75	1812.02	1613.55	1571.52	2835.35	1695.79	1434.44	1845.95

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1114.22	1337.88	1336.11	0.26	0.26	-0.0
7h	1247.28	1340.74	1387.07	0.1	0.15	0.05
23h	1128.85	2601.26	1178.6	1.2	0.06	-1.14

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1114.22	1247.28	1128.85	0.16	0.02	-0.14
Ebov	1337.88	1340.74	2601.26	0.0	0.96	0.96
Marv	1336.11	1387.07	1178.6	0.05	-0.18	-0.23

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	807.53	769.25	908.72	-0.07	0.17	0.24
7h	853.32	877.07	835.47	0.04	-0.03	-0.07
23h	1005.1	1284.18	1084.76	0.35	0.11	-0.24

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	807.53	853.32	1005.1	0.08	0.32	0.24
Ebov	769.25	877.07	1284.18	0.19	0.74	0.55
Marv	908.72	835.47	1084.76	-0.12	0.26	0.38

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material