CLTC

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CLTC	CLH17, CLTCL2, KIAA0034,Hc	clathrin, heavy chain (Hc)	NM_004859	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.

The gene is moderately expressed in human cells and more in bat cells regardless of the infection state.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	1558	1465	1136	1252	1485	1459	1487	1701	1092
Read_Max	R. aegyptiacus	Transcriptome	1418	1068	746	1148	829	1129	969	1100	1054
Read_Max	R. aegyptiacus	Genome	1578	1143	634	1015	685	640	795	1298	1128
DESeq	H. sapiens	Genome	38593.34	34259.55	32919.09	33299.82	33757.15	37715.33	32535.65	31449.05	34941.8
DESeq	R. aegyptiacus	Transcriptome	23076.3	18891.84	19907.16	23030.97	21229.32	27472.64	22717.44	22412.73	22199.36
DESeq	R. aegyptiacus	Genome	24143.7	23146.6	18844.37	20997.85	22062.62	28682.47	23757.99	22104.16	22600.89

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	38593.34	33299.82	32535.65	-0.21	-0.25	-0.03
7h	34259.55	33757.15	31449.05	-0.02	-0.12	-0.1
23h	32919.09	37715.33	34941.8	0.2	0.09	-0.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	38593.34	34259.55	32919.09	-0.17	-0.23	-0.06
Ebov	33299.82	33757.15	37715.33	0.02	0.18	0.16
Marv	32535.65	31449.05	34941.8	-0.05	0.1	0.15

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	23076.3	23030.97	22717.44	-0.0	-0.02	-0.02
7h	18891.84	21229.32	22412.73	0.17	0.25	0.08
23h	19907.16	27472.64	22199.36	0.46	0.16	-0.31

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	23076.3	18891.84	19907.16	-0.29	-0.21	0.08
Ebov	23030.97	21229.32	27472.64	-0.12	0.25	0.37
Marv	22717.44	22412.73	22199.36	-0.02	-0.03	-0.01

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material