C3

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
C3	AHUS5, ARMD9, ASPa, C3b, CPAMD1, HEL-S-62p,CPAMD1, C3a	complement component 3	NM_000064	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.

This gene is strongly down-regulated in Marburg infected human cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	204	293	289	278	390	536	352	439	156
Read_Max	R. aegyptiacus	Transcriptome	20	37	22	19	22	27	20	22	22
Read_Max	R. aegyptiacus	Genome	12	9	14	20	11	12	9	16	18
DESeq	H. sapiens	Genome	5024.19	7657.19	7181.11	7650.42	7213.5	12729.92	7816.02	7702.74	3661.01
DESeq	R. aegyptiacus	Transcriptome	254.72	393.12	446.86	239.99	184.98	357.72	216.81	255.47	294.03
DESeq	R. aegyptiacus	Genome	97.97	68.45	179.64	174.78	72.55	167.09	64.1	95.15	138.7

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5024.19	7650.42	7816.02	0.61	0.64	0.03
7h	7657.19	7213.5	7702.74	-0.09	0.01	0.09
23h	7181.11	12729.92	3661.01	0.83	-0.97	-1.8

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5024.19	7657.19	7181.11	0.61	0.52	-0.09
Ebov	7650.42	7213.5	12729.92	-0.08	0.73	0.82
Marv	7816.02	7702.74	3661.01	-0.02	-1.09	-1.07

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	254.72	239.99	216.81	-0.09	-0.23	-0.15
7h	393.12	184.98	255.47	-1.09	-0.62	0.47
23h	446.86	357.72	294.03	-0.32	-0.6	-0.28

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	254.72	393.12	446.86	0.63	0.81	0.18
Ebov	239.99	184.98	357.72	-0.38	0.58	0.95
Marv	216.81	255.47	294.03	0.24	0.44	0.2

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

C3