ETF1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ETF1 eRF1, TB3-1, RF1 eukaryotic translation termination factor 1 NM_004730 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X

This genes is rather highly expressed (with a slight increase in later time points of the human cells Ebola data) and shows a good conservation and transcript hits in the bat transcriptome assembly.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome692 564 622 579 767 960 778 793 617
Read_Max
batR. aegyptiacusTranscriptome 1028 829 446 870 725 921 913 1076 759
Read_Max
bat_genomeR. aegyptiacusGenome 1087 902 400 820 608 539 766 1286 854
DESeq
humanH. sapiensGenome 8104.07 6717.88 7107.64 7985.78 7037.09 10475.74 7837.95 7026.49 8723.7
DESeq
batR. aegyptiacusTranscriptome 6794.38 6028.06 5202.3 5967.49 6564.97 7857.92 8156.05 6724.68 6026.87
DESeq
bat_genomeR. aegyptiacusGenome 10244.79 8404.92 6860.92 9630.93 9462.58 11255.24 12065.1 8908.75 8516.54

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8104.07 7985.78 7837.95 -0.02 -0.05 -0.03
7h 6717.88 7037.09 7026.49 0.07 0.06 -0.0
23h 7107.64 10475.74 8723.7 0.56 0.3 -0.26

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8104.07 6717.88 7107.64 -0.27 -0.19 0.08
Ebov 7985.78 7037.09 10475.74 -0.18 0.39 0.57
Marv 7837.95 7026.49 8723.7 -0.16 0.15 0.31

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6794.38 5967.49 8156.05 -0.19 0.26 0.45
7h 6028.06 6564.97 6724.68 0.12 0.16 0.03
23h 5202.3 7857.92 6026.87 0.59 0.21 -0.38

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6794.38 6028.06 5202.3 -0.17 -0.39 -0.21
Ebov 5967.49 6564.97 7857.92 0.14 0.4 0.26
Marv 8156.05 6724.68 6026.87 -0.28 -0.44 -0.16