ETF1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| ETF1 | eRF1, TB3-1, RF1 | eukaryotic translation termination factor 1 | NM_004730 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X
This genes is rather highly expressed (with a slight increase in later time points of the human cells Ebola data) and shows a good conservation and transcript hits in the bat transcriptome assembly.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 692 | 564 | 622 | 579 | 767 | 960 | 778 | 793 | 617 |
Read_Max |  | R. aegyptiacus | Transcriptome | 1028 | 829 | 446 | 870 | 725 | 921 | 913 | 1076 | 759 |
Read_Max |  | R. aegyptiacus | Genome | 1087 | 902 | 400 | 820 | 608 | 539 | 766 | 1286 | 854 |
DESeq | | H. sapiens | Genome | 8104.07 | 6717.88 | 7107.64 | 7985.78 | 7037.09 | 10475.74 | 7837.95 | 7026.49 | 8723.7 |
DESeq | | R. aegyptiacus | Transcriptome | 6794.38 | 6028.06 | 5202.3 | 5967.49 | 6564.97 | 7857.92 | 8156.05 | 6724.68 | 6026.87 |
DESeq | | R. aegyptiacus | Genome | 10244.79 | 8404.92 | 6860.92 | 9630.93 | 9462.58 | 11255.24 | 12065.1 | 8908.75 | 8516.54 |