TP73

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TP73 B7Z9C1, NM_005427, NP_001191121, O15350, O15351, P73, P73_HUMAN, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8,P73 tumor protein p73 NM_005427 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens tumor protein p73 (TP73), transcript variant 1 gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

This gene is first upregulated in all samples and holds a level of transcripts after 7h or decrease slightly.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome5 5 7 5 6 11 4 4 2
Read_Max
batR. aegyptiacusTranscriptome 1 2 2 NA 3 1 NA 1 2
Read_Max
bat_genomeR. aegyptiacusGenome 1 2 4 2 2 1 2 3 2
DESeq
humanH. sapiensGenome 11.15 8.14 2.99 11.27 15.63 22.05 9.77 8.99 10.79
DESeq
batR. aegyptiacusTranscriptome 1.84 2.82 4.66 1.0 5.38 3.57 1.0 3.48 2.75
DESeq
bat_genomeR. aegyptiacusGenome 4.3 7.3 21.2 5.92 6.7 3.92 5.62 8.72 14.56

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 11.15 11.27 9.77 0.02 -0.19 -0.21
7h 8.14 15.63 8.99 0.94 0.14 -0.8
23h 2.99 22.05 10.79 2.88 1.85 -1.03

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 11.15 8.14 2.99 -0.45 -1.9 -1.44
Ebov 11.27 15.63 22.05 0.47 0.97 0.5
Marv 9.77 8.99 10.79 -0.12 0.14 0.26

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.84 1.0 1.0 -0.88 -0.88 0.0
7h 2.82 5.38 3.48 0.93 0.3 -0.63
23h 4.66 3.57 2.75 -0.38 -0.76 -0.38

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.84 2.82 4.66 0.62 1.34 0.72
Ebov 1.0 5.38 3.57 2.43 1.84 -0.59
Marv 1.0 3.48 2.75 1.8 1.46 -0.34