PAK4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PAK4		p21 protein (Cdc42/Rac)-activated kinase 4		pdf

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Description

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

This gene is upregulated in Ebola infected cells in human cells after 23 h but not in bat cells. We observed a transcript isoform in human cells that is only present 3 h after Ebola and Marburg infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	157	146	133	150	144	294	190	231	107
Read_Max	R. aegyptiacus	Transcriptome	69	63	47	76	59	65	41	82	80
Read_Max	R. aegyptiacus	Genome	74	61	52	65	56	37	30	74	91
DESeq	H. sapiens	Genome	2316.74	1930.6	1602.43	2026.85	1629.34	3157.9	2077.34	2104.09	1467.83
DESeq	R. aegyptiacus	Transcriptome	453.0	503.86	461.52	521.1	490.51	496.31	404.8	471.94	489.09
DESeq	R. aegyptiacus	Genome	706.42	700.03	695.13	803.81	743.35	778.02	615.12	658.15	694.37

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2316.74	2026.85	2077.34	-0.19	-0.16	0.04
7h	1930.6	1629.34	2104.09	-0.24	0.12	0.37
23h	1602.43	3157.9	1467.83	0.98	-0.13	-1.11

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2316.74	1930.6	1602.43	-0.26	-0.53	-0.27
Ebov	2026.85	1629.34	3157.9	-0.31	0.64	0.95
Marv	2077.34	2104.09	1467.83	0.02	-0.5	-0.52

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	453.0	521.1	404.8	0.2	-0.16	-0.36
7h	503.86	490.51	471.94	-0.04	-0.09	-0.06
23h	461.52	496.31	489.09	0.1	0.08	-0.02

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	453.0	503.86	461.52	0.15	0.03	-0.13
Ebov	521.1	490.51	496.31	-0.09	-0.07	0.02
Marv	404.8	471.94	489.09	0.22	0.27	0.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material