CDK9

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
CDK9	TAK, C-2k, CTK1, CDC2L4, PITALRE,PITALRE, TAK	cyclin-dependent kinase 9		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

This gene is upregulated in human cells and bat cells for Ebola. For Marburg only upregulated in bat cells. We found hsa-mir-2861 in 5' which was not expressed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	142	142	144	112	164	149	149	198	135
Read_Max	R. aegyptiacus	Transcriptome	110	107	118	113	93	107	73	113	145
Read_Max	R. aegyptiacus	Genome	125	134	104	96	82	70	67	160	173
DESeq	H. sapiens	Genome	1490.71	1485.93	1397.9	1324.19	1219.61	1240.6	1283.47	1464.61	1565.69
DESeq	R. aegyptiacus	Transcriptome	614.3	646.37	1002.66	748.19	725.95	838.92	637.3	626.44	872.21
DESeq	R. aegyptiacus	Genome	773.45	956.49	1104.62	799.86	936.44	1041.72	805.16	835.77	1033.42

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1490.71	1324.19	1283.47	-0.17	-0.22	-0.05
7h	1485.93	1219.61	1464.61	-0.28	-0.02	0.26
23h	1397.9	1240.6	1565.69	-0.17	0.16	0.34

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1490.71	1485.93	1397.9	-0.0	-0.09	-0.09
Ebov	1324.19	1219.61	1240.6	-0.12	-0.09	0.02
Marv	1283.47	1464.61	1565.69	0.19	0.29	0.1

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	614.3	748.19	637.3	0.28	0.05	-0.23
7h	646.37	725.95	626.44	0.17	-0.05	-0.21
23h	1002.66	838.92	872.21	-0.26	-0.2	0.06

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	614.3	646.37	1002.66	0.07	0.71	0.63
Ebov	748.19	725.95	838.92	-0.04	0.17	0.21
Marv	637.3	626.44	872.21	-0.02	0.45	0.48

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material