TBK1
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| TBK1 | NAK, T2K | TANK-binding kinase 1 | NM_013254 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.
TBK1 is well expressed in both human cells and bat cells. There are minor fluctuations visible in Ebola-infected cells, but this is likely not very significant.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 169 | 152 | 220 | 166 | 277 | 159 | 205 | 220 | 205 |
Read_Max |  | R. aegyptiacus | Transcriptome | 207 | 227 | 155 | 152 | 143 | 144 | 168 | 179 | 170 |
Read_Max |  | R. aegyptiacus | Genome | 216 | 160 | 122 | 203 | 115 | 88 | 139 | 213 | 169 |
DESeq | | H. sapiens | Genome | 2303.55 | 2178.43 | 2586.32 | 2301.76 | 2705.69 | 1813.02 | 2343.14 | 2243.18 | 2712.84 |
DESeq | | R. aegyptiacus | Transcriptome | 1672.04 | 1612.15 | 1569.45 | 1657.44 | 1606.4 | 1420.2 | 1937.7 | 1726.95 | 1341.05 |
DESeq | | R. aegyptiacus | Genome | 1744.56 | 1706.72 | 1571.02 | 1765.62 | 1622.86 | 1516.89 | 1993.8 | 1792.06 | 1438.4 |