TBK1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
TBK1 NAK, T2K TANK-binding kinase 1 NM_013254 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

TBK1 is well expressed in both human cells and bat cells. There are minor fluctuations visible in Ebola-infected cells, but this is likely not very significant.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome169 152 220 166 277 159 205 220 205
Read_Max
batR. aegyptiacusTranscriptome 207 227 155 152 143 144 168 179 170
Read_Max
bat_genomeR. aegyptiacusGenome 216 160 122 203 115 88 139 213 169
DESeq
humanH. sapiensGenome 2303.55 2178.43 2586.32 2301.76 2705.69 1813.02 2343.14 2243.18 2712.84
DESeq
batR. aegyptiacusTranscriptome 1672.04 1612.15 1569.45 1657.44 1606.4 1420.2 1937.7 1726.95 1341.05
DESeq
bat_genomeR. aegyptiacusGenome 1744.56 1706.72 1571.02 1765.62 1622.86 1516.89 1993.8 1792.06 1438.4

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2303.55 2301.76 2343.14 -0.0 0.02 0.03
7h 2178.43 2705.69 2243.18 0.31 0.04 -0.27
23h 2586.32 1813.02 2712.84 -0.51 0.07 0.58

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2303.55 2178.43 2586.32 -0.08 0.17 0.25
Ebov 2301.76 2705.69 1813.02 0.23 -0.34 -0.58
Marv 2343.14 2243.18 2712.84 -0.06 0.21 0.27

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1672.04 1657.44 1937.7 -0.01 0.21 0.23
7h 1612.15 1606.4 1726.95 -0.01 0.1 0.1
23h 1569.45 1420.2 1341.05 -0.14 -0.23 -0.08

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1672.04 1612.15 1569.45 -0.05 -0.09 -0.04
Ebov 1657.44 1606.4 1420.2 -0.05 -0.22 -0.18
Marv 1937.7 1726.95 1341.05 -0.17 -0.53 -0.36