RAF1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
RAF1 NS5, CRAF, Raf-1, c-Raf, CMD1NN,Raf-1 Raf-1 proto-oncogene, serine/threonine kinase NM_002880 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Well expressed in human cells and in the bat cells homolog. Some minor fluctuations in expression levels, but nothing very significant. There is some intron expression in human cells between exons 4 to 5, but in all samples.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome437 491 532 472 696 564 568 646 439
Read_Max
batR. aegyptiacusTranscriptome 337 301 205 274 211 289 210 315 292
Read_Max
bat_genomeR. aegyptiacusGenome 374 312 203 304 185 173 198 388 332
DESeq
humanH. sapiensGenome 8622.63 9619.42 9575.8 9421.9 10314.91 10492.85 9692.36 9502.08 8314.85
DESeq
batR. aegyptiacusTranscriptome 2612.16 2561.59 2141.13 2380.82 2221.84 2267.1 2430.49 2356.52 2258.62
DESeq
bat_genomeR. aegyptiacusGenome 4500.63 4116.21 3875.1 4803.12 3933.26 4095.07 4251.86 4154.24 4080.61

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8622.63 9421.9 9692.36 0.13 0.17 0.04
7h 9619.42 10314.91 9502.08 0.1 -0.02 -0.12
23h 9575.8 10492.85 8314.85 0.13 -0.2 -0.34

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8622.63 9619.42 9575.8 0.16 0.15 -0.01
Ebov 9421.9 10314.91 10492.85 0.13 0.16 0.02
Marv 9692.36 9502.08 8314.85 -0.03 -0.22 -0.19

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2612.16 2380.82 2430.49 -0.13 -0.1 0.03
7h 2561.59 2221.84 2356.52 -0.21 -0.12 0.08
23h 2141.13 2267.1 2258.62 0.08 0.08 -0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2612.16 2561.59 2141.13 -0.03 -0.29 -0.26
Ebov 2380.82 2221.84 2267.1 -0.1 -0.07 0.03
Marv 2430.49 2356.52 2258.62 -0.04 -0.11 -0.06