Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

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RAF1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
RAF1	NS5, CRAF, Raf-1, c-Raf, CMD1NN,Raf-1	Raf-1 proto-oncogene, serine/threonine kinase	NM_002880	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Well expressed in human cells and in the bat cells homolog. Some minor fluctuations in expression levels, but nothing very significant. There is some intron expression in human cells between exons 4 to 5, but in all samples.

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