RRAGB
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| RRAGB | RAGB, bA465E19.1 | Ras-related GTP binding B | NM_016656 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified.
For this gene we see a higher expression for Marburg virus, low expression in human cells, but upregulated in bat cells, and intronic expression in human cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 34 | 52 | 37 | 12 | 55 | 28 | 69 | 31 | 15 |
Read_Max |  | R. aegyptiacus | Transcriptome | 123 | 114 | 119 | 117 | 106 | 175 | 118 | 161 | 166 |
Read_Max |  | R. aegyptiacus | Genome | 218 | 205 | 160 | 168 | 133 | 159 | 137 | 306 | 270 |
DESeq | | H. sapiens | Genome | 94.36 | 108.09 | 118.15 | 77.43 | 133.51 | 191.81 | 115.04 | 92.13 | 130.39 |
DESeq | | R. aegyptiacus | Transcriptome | 351.34 | 356.81 | 423.65 | 341.63 | 370.05 | 455.25 | 413.7 | 435.59 | 432.23 |
DESeq | | R. aegyptiacus | Genome | 1644.01 | 1911.16 | 2099.89 | 1645.15 | 1759.03 | 1862.82 | 1642.94 | 1996.64 | 1915.3 |